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Breast cancer genome and transcriptome integration implicates specific mutational signatures with immune cell infiltration.
Smid, Marcel; Rodríguez-González, F Germán; Sieuwerts, Anieta M; Salgado, Roberto; Prager-Van der Smissen, Wendy J C; Vlugt-Daane, Michelle van der; van Galen, Anne; Nik-Zainal, Serena; Staaf, Johan; Brinkman, Arie B; van de Vijver, Marc J; Richardson, Andrea L; Fatima, Aquila; Berentsen, Kim; Butler, Adam; Martin, Sancha; Davies, Helen R; Debets, Reno; Gelder, Marion E Meijer-Van; van Deurzen, Carolien H M; MacGrogan, Gaëtan; Van den Eynden, Gert G G M; Purdie, Colin; Thompson, Alastair M; Caldas, Carlos; Span, Paul N; Simpson, Peter T; Lakhani, Sunil R; Van Laere, Steven; Desmedt, Christine; Ringnér, Markus; Tommasi, Stefania; Eyford, Jorunn; Broeks, Annegien; Vincent-Salomon, Anne; Futreal, P Andrew; Knappskog, Stian; King, Tari; Thomas, Gilles; Viari, Alain; Langerød, Anita; Børresen-Dale, Anne-Lise; Birney, Ewan; Stunnenberg, Hendrik G; Stratton, Mike; Foekens, John A; Martens, John W M.
Affiliation
  • Smid M; Department of Medical Oncology, Erasmus MC Cancer Institute and Cancer Genomics Netherlands, Erasmus University Medical Center, 3015CN Rotterdam, The Netherlands.
  • Rodríguez-González FG; Department of Medical Oncology, Erasmus MC Cancer Institute and Cancer Genomics Netherlands, Erasmus University Medical Center, 3015CN Rotterdam, The Netherlands.
  • Sieuwerts AM; Department of Medical Oncology, Erasmus MC Cancer Institute and Cancer Genomics Netherlands, Erasmus University Medical Center, 3015CN Rotterdam, The Netherlands.
  • Salgado R; Breast Cancer Translational Research Laboratory, Université Libre de Bruxelles, Institut Jules Bordet, Bd de Waterloo 121, B-1000 Brussels, Belgium.
  • Prager-Van der Smissen WJ; Department of Pathology/TCRU GZA, 2610 Antwerp, Belgium.
  • Vlugt-Daane MV; Department of Medical Oncology, Erasmus MC Cancer Institute and Cancer Genomics Netherlands, Erasmus University Medical Center, 3015CN Rotterdam, The Netherlands.
  • van Galen A; Department of Medical Oncology, Erasmus MC Cancer Institute and Cancer Genomics Netherlands, Erasmus University Medical Center, 3015CN Rotterdam, The Netherlands.
  • Nik-Zainal S; Department of Medical Oncology, Erasmus MC Cancer Institute and Cancer Genomics Netherlands, Erasmus University Medical Center, 3015CN Rotterdam, The Netherlands.
  • Staaf J; Wellcome Trust Sanger Institute, Hinxton CB10 1SA, Cambridge, UK.
  • Brinkman AB; East Anglian Medical Genetics Service, Cambridge University Hospitals NHS Foundation Trust, Cambridge CB2 9NB, UK.
  • van de Vijver MJ; Division of Oncology and Pathology, Department of Clinical Sciences Lund, Lund University, SE-223 81 Lund, Sweden.
  • Richardson AL; Faculty of Science, Department of Molecular Biology, Radboud Institute for Molecular Life Sciences, Radboud University Nijmegen, 6525GA, Nijmegen, The Netherlands.
  • Fatima A; Department of Pathology, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.
  • Berentsen K; Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.
  • Butler A; Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA.
  • Martin S; Department of Pathology, Erasmus MC Cancer Institute, Erasmus University Medical Center, 3015CN Rotterdam, The Netherlands.
  • Davies HR; Faculty of Science, Department of Molecular Biology, Radboud Institute for Molecular Life Sciences, Radboud University Nijmegen, 6525GA, Nijmegen, The Netherlands.
  • Debets R; Wellcome Trust Sanger Institute, Hinxton CB10 1SA, Cambridge, UK.
  • Gelder ME; Wellcome Trust Sanger Institute, Hinxton CB10 1SA, Cambridge, UK.
  • van Deurzen CH; Wellcome Trust Sanger Institute, Hinxton CB10 1SA, Cambridge, UK.
  • MacGrogan G; Department of Medical Oncology, Erasmus MC Cancer Institute and Cancer Genomics Netherlands, Erasmus University Medical Center, 3015CN Rotterdam, The Netherlands.
  • Van den Eynden GG; Department of Medical Oncology, Erasmus MC Cancer Institute and Cancer Genomics Netherlands, Erasmus University Medical Center, 3015CN Rotterdam, The Netherlands.
  • Purdie C; Department of Pathology, Erasmus MC Cancer Institute, Erasmus University Medical Center, 3015CN Rotterdam, The Netherlands.
  • Thompson AM; Département de Biopathologie,Institut Bergonié, CS 61283 33076 Bordeaux, France.
  • Caldas C; Department of Pathology/TCRU GZA, 2610 Antwerp, Belgium.
  • Span PN; Molecular Immunology Unit, Jules Bordet Institute, B-1000 Brussels, Belgium.
  • Simpson PT; Department of Pathology, Ninewells Hospital &Medical School, Dundee DD1 9SY, UK.
  • Lakhani SR; Department of Pathology, Ninewells Hospital &Medical School, Dundee DD1 9SY, UK.
  • Van Laere S; Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK.
  • Desmedt C; Department of Radiation Oncology, Radboud University Medical Center, 6525GA, Nijmegen, The Netherlands.
  • Ringnér M; Department of Laboratory Medicine, Radboud University Medical Center, 6525GA, Nijmegen, The Netherlands.
  • Tommasi S; The University of Queensland: UQ Centre for Clinical Research and School of Medicine, Brisbane 4029, Australia.
  • Eyford J; The University of Queensland: UQ Centre for Clinical Research and School of Medicine, Brisbane 4029, Australia.
  • Broeks A; Pathology Queensland, The Royal Brisbane and Women's Hospital, Brisbane 4029, Australia.
  • Vincent-Salomon A; Center for Oncological Research, University of Antwerp &GZA Hospitals Sint-Augustinus, 2610 Wilrijk, Belgium.
  • Futreal PA; Breast Cancer Translational Research Laboratory, Université Libre de Bruxelles, Institut Jules Bordet, Bd de Waterloo 121, B-1000 Brussels, Belgium.
  • Knappskog S; Division of Oncology and Pathology, Department of Clinical Sciences Lund, Lund University, SE-223 81 Lund, Sweden.
  • King T; IRCCS Istituto Tumori 'Giovanni Paolo II', 70124 Bari, Italy.
  • Thomas G; Cancer Research Laboratory, Faculty of Medicine, University of Iceland, 101 Reykjavik, Iceland.
  • Viari A; The Netherlands Cancer Institute, 1066CX Amsterdam, The Netherlands.
  • Langerød A; Department of Pathology and INSERM U934, Institut Curie, 26 rue d'Ulm, 75248 Paris Cedex 05, France.
  • Børresen-Dale AL; Department of Genomic Medicine, UT MD Anderson Cancer Center, Houston, TX, 77230, USA.
  • Birney E; Department of Clinical Science, University of Bergen, 5020 Bergen, Norway.
  • Stunnenberg HG; Department of Oncology, Haukeland University Hospital, 5021 Bergen, Norway.
  • Stratton M; Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, New York 10065, USA.
  • Foekens JA; Synergie Lyon Cancer,Centre Léon Bérard, 28 rue Laënnec, Cedex 08 Lyon, France.
  • Martens JW; Synergie Lyon Cancer,Centre Léon Bérard, 28 rue Laënnec, Cedex 08 Lyon, France.
Nat Commun ; 7: 12910, 2016 Sep 26.
Article in En | MEDLINE | ID: mdl-27666519
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Nat Commun Year: 2016 Document type: Article
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Nat Commun Year: 2016 Document type: Article