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First-in-human phase I study of copanlisib (BAY 80-6946), an intravenous pan-class I phosphatidylinositol 3-kinase inhibitor, in patients with advanced solid tumors and non-Hodgkin's lymphomas.
Patnaik, A; Appleman, L J; Tolcher, A W; Papadopoulos, K P; Beeram, M; Rasco, D W; Weiss, G J; Sachdev, J C; Chadha, M; Fulk, M; Ejadi, S; Mountz, J M; Lotze, M T; Toledo, F G S; Chu, E; Jeffers, M; Peña, C; Xia, C; Reif, S; Genvresse, I; Ramanathan, R K.
Affiliation
  • Patnaik A; South Texas Accelerated Research Therapeutics (START) Center for Cancer Care, San Antonio amita.patnaik@start.stoh.com.
  • Appleman LJ; University of Pittsburgh, Pittsburgh.
  • Tolcher AW; South Texas Accelerated Research Therapeutics (START) Center for Cancer Care, San Antonio.
  • Papadopoulos KP; South Texas Accelerated Research Therapeutics (START) Center for Cancer Care, San Antonio.
  • Beeram M; South Texas Accelerated Research Therapeutics (START) Center for Cancer Care, San Antonio.
  • Rasco DW; South Texas Accelerated Research Therapeutics (START) Center for Cancer Care, San Antonio.
  • Weiss GJ; Virginia G. Piper Cancer Center Clinical Trials at Scottsdale Healthcare/TGen, Scottsdale Cancer Treatment Centers of America, Goodyear.
  • Sachdev JC; Virginia G. Piper Cancer Center Clinical Trials at Scottsdale Healthcare/TGen, Scottsdale.
  • Chadha M; Virginia G. Piper Cancer Center Clinical Trials at Scottsdale Healthcare/TGen, Scottsdale.
  • Fulk M; Virginia G. Piper Cancer Center Clinical Trials at Scottsdale Healthcare/TGen, Scottsdale.
  • Ejadi S; Virginia G. Piper Cancer Center Clinical Trials at Scottsdale Healthcare/TGen, Scottsdale.
  • Mountz JM; University of Pittsburgh, Pittsburgh.
  • Lotze MT; University of Pittsburgh, Pittsburgh.
  • Toledo FG; University of Pittsburgh, Pittsburgh.
  • Chu E; University of Pittsburgh, Pittsburgh.
  • Jeffers M; Bayer HealthCare Pharmaceuticals, Inc., Whippany, USA.
  • Peña C; Bayer HealthCare Pharmaceuticals, Inc., Whippany, USA.
  • Xia C; Bayer HealthCare Pharmaceuticals, Inc., Whippany, USA.
  • Reif S; Bayer Pharma AG, Berlin, Germany.
  • Genvresse I; Bayer Pharma AG, Berlin, Germany.
  • Ramanathan RK; Virginia G. Piper Cancer Center Clinical Trials at Scottsdale Healthcare/TGen, Scottsdale.
Ann Oncol ; 27(10): 1928-40, 2016 10.
Article in En | MEDLINE | ID: mdl-27672108
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrimidines / Quinazolines / Lymphoma, Non-Hodgkin / Enzyme Inhibitors / Class I Phosphatidylinositol 3-Kinases / Neoplasms Type of study: Clinical_trials Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: En Journal: Ann Oncol Year: 2016 Document type: Article
Fulltext
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrimidines / Quinazolines / Lymphoma, Non-Hodgkin / Enzyme Inhibitors / Class I Phosphatidylinositol 3-Kinases / Neoplasms Type of study: Clinical_trials Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: En Journal: Ann Oncol Year: 2016 Document type: Article