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Propentofylline reduces glial scar development following gliotoxic damage in the rat brainstem.
Bondan, Eduardo Fernandes; Martins, Maria de Fátima Monteiro; Dossa, Pietro Domingues; Viebig, Lígia Bocamino; Cardoso, Carolina Vieira; Martins, João Lopes; Bernardi, Maria Martha.
Affiliation
  • Bondan EF; Universidade Paulista, Departamento de Patologia Ambiental e Experimental, São Paulo SP, Brasil.
  • Martins MF; Universidade Cruzeiro do Sul, Departamento de Medicina Veterinária, São Paulo SP, Brasil.
  • Dossa PD; Universidade Paulista, Departamento de Patologia Ambiental e Experimental, São Paulo SP, Brasil.
  • Viebig LB; Universidade Cruzeiro do Sul, Departamento de Medicina Veterinária, São Paulo SP, Brasil.
  • Cardoso CV; Universidade Paulista, Departamento de Patologia Ambiental e Experimental, São Paulo SP, Brasil.
  • Martins JL; Universidade Paulista, Departamento de Patologia Ambiental e Experimental, São Paulo SP, Brasil.
  • Bernardi MM; Universidade Paulista, Departamento de Patologia Ambiental e Experimental, São Paulo SP, Brasil.
Arq Neuropsiquiatr ; 74(9): 730-736, 2016 Sep.
Article in En | MEDLINE | ID: mdl-27706422
ABSTRACT

OBJECTIVE:

This study aimed to evaluate the effect of propentofylline administration on astrocytic response following gliotoxic injury.

METHOD:

Wistar rats were injected with ethidium bromide into the cisterna pontis and treated or not with propentofylline (12.5mg/kg/day, intraperitoneal) during the experimental period. Brainstem sections were collected from 15 to 31 days after gliotoxic injection and processed for GFAP immunohistochemistry. RESULTS AND

CONCLUSION:

Results demonstrate that propentofylline decreased astrocytic activation until the 21st day, suggesting that this drug may have a role in reducing glial scar development following injury.
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Full text: 1 Collection: 01-internacional Health context: 1_ASSA2030 Database: MEDLINE Main subject: Xanthines / Brain Stem / Astrocytes / Neuroprotective Agents Type of study: Evaluation_studies / Prognostic_studies Limits: Animals Language: En Journal: Arq Neuropsiquiatr Year: 2016 Document type: Article
Fulltext
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Full text: 1 Collection: 01-internacional Health context: 1_ASSA2030 Database: MEDLINE Main subject: Xanthines / Brain Stem / Astrocytes / Neuroprotective Agents Type of study: Evaluation_studies / Prognostic_studies Limits: Animals Language: En Journal: Arq Neuropsiquiatr Year: 2016 Document type: Article