Brief Report: Pharmacokinetic/Pharmacodynamic Investigation of Single-Dose Oral Maraviroc in the Context of HIV-1 Pre-exposure Prophylaxis.

Fox, Julie; Tiraboschi, Juan M; Herrera, Carolina; Else, Laura; Egan, Deirdre; Dickinson, Laura; Jackson, Akil; Olejniczak, Natalia; Back, David; Khoo, Saye; Shattock, Robin; Boffito, Marta

Fox, Julie; Tiraboschi, Juan M; Herrera, Carolina; Else, Laura; Egan, Deirdre; Dickinson, Laura; Jackson, Akil; Olejniczak, Natalia; Back, David; Khoo, Saye; Shattock, Robin; Boffito, Marta.

Affiliation

Fox J; *Guys and St. Thomas' NHS Foundation Trust, London, United Kingdom; Imperial College London, London, United Kingdom; University of Liverpool, Liverpool, United Kingdom; and §St Stephen's Centre, Chelsea and Westminster Hospital NHS Foundation Trust, London, United Kingdom.

J Acquir Immune Defic Syndr ; 73(3): 252-257, 2016 11 01.

Article in En | MEDLINE | ID: mdl-27727157

Subject(s)

CCR5 Receptor Antagonists/pharmacokinetics; Cyclohexanes/pharmacokinetics; HIV Fusion Inhibitors/pharmacokinetics; HIV Infections/prevention & control; HIV Infections/virology; Pre-Exposure Prophylaxis; Triazoles/pharmacokinetics; Administration, Oral; Adult; CCR5 Receptor Antagonists/administration & dosage; CCR5 Receptor Antagonists/pharmacology; Cyclohexanes/administration & dosage; Cyclohexanes/pharmacology; Female; HIV Fusion Inhibitors/administration & dosage; HIV Fusion Inhibitors/pharmacology; HIV-1/drug effects; Healthy Volunteers; Humans; Intestinal Mucosa/drug effects; Intestinal Mucosa/virology; Male; Maraviroc; Models, Biological; Randomized Controlled Trials as Topic; Rectum/drug effects; Rectum/virology; Saliva/drug effects; Saliva/virology; Treatment Outcome; Triazoles/administration & dosage; Triazoles/pharmacology; Urethra/drug effects; Urethra/virology; Vagina/drug effects; Vagina/virology

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Collection: 01-internacional Health context: 2_ODS3 Database: MEDLINE Main subject: Triazoles / HIV Infections / Cyclohexanes / HIV Fusion Inhibitors / CCR5 Receptor Antagonists / Pre-Exposure Prophylaxis Type of study: Clinical_trials Limits: Adult / Female / Humans / Male Language: En Journal: J Acquir Immune Defic Syndr Year: 2016 Document type: Article

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