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Acquired CDK6 amplification promotes breast cancer resistance to CDK4/6 inhibitors and loss of ER signaling and dependence.
Yang, C; Li, Z; Bhatt, T; Dickler, M; Giri, D; Scaltriti, M; Baselga, J; Rosen, N; Chandarlapaty, S.
Affiliation
  • Yang C; Oncology Department of the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
  • Li Z; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center (MSKCC), New York, NY, USA.
  • Bhatt T; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center (MSKCC), New York, NY, USA.
  • Dickler M; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center (MSKCC), New York, NY, USA.
  • Giri D; Breast Medicine Service, Department of Medicine, MSKCC, New York, NY, USA.
  • Scaltriti M; Weill Cornell Medical College, New York, NY USA.
  • Baselga J; Weill Cornell Medical College, New York, NY USA.
  • Rosen N; Department of Pathology, Memorial Sloan Kettering Cancer Center (MSKCC), New York, NY, USA.
  • Chandarlapaty S; Weill Cornell Medical College, New York, NY USA.
Oncogene ; 36(16): 2255-2264, 2017 04 20.
Article in En | MEDLINE | ID: mdl-27748766
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Breast Neoplasms / Receptors, Estrogen / Drug Resistance, Neoplasm / Protein Kinase Inhibitors / Cyclin-Dependent Kinase 4 / Cyclin-Dependent Kinase 6 Limits: Female / Humans Language: En Journal: Oncogene Year: 2017 Document type: Article
Fulltext
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Breast Neoplasms / Receptors, Estrogen / Drug Resistance, Neoplasm / Protein Kinase Inhibitors / Cyclin-Dependent Kinase 4 / Cyclin-Dependent Kinase 6 Limits: Female / Humans Language: En Journal: Oncogene Year: 2017 Document type: Article