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Targeted vaccination against the bevacizumab binding site on VEGF using 3D-structured peptides elicits efficient antitumor activity.
Wentink, Madelon Q; Hackeng, Tilman M; Tabruyn, Sebastien P; Puijk, Wouter C; Schwamborn, Klaus; Altschuh, Daniele; Meloen, Rob H; Schuurman, Teun; Griffioen, Arjan W; Timmerman, Peter.
Affiliation
  • Wentink MQ; Angiogenesis Laboratory, Department of Medical Oncology, Vrije Universiteit Medical Center, 1081 HZ Amsterdam, The Netherlands.
  • Hackeng TM; Department of Biochemistry, Maastricht University Medical Center, 6229 HX Maastricht, The Netherlands.
  • Tabruyn SP; Angiogenesis Laboratory, Department of Medical Oncology, Vrije Universiteit Medical Center, 1081 HZ Amsterdam, The Netherlands.
  • Puijk WC; Pepscan Therapeutics B.V., 8243 RC Lelystad, The Netherlands.
  • Schwamborn K; Pepscan Therapeutics B.V., 8243 RC Lelystad, The Netherlands.
  • Altschuh D; Equipe labellisée Ligue 2015, UMR 7242, Université de Strasbourg, CNRS, École Supérieure de Biotechnologie de Strasbourg, 67412 Illkirch, France.
  • Meloen RH; Pepscan Therapeutics B.V., 8243 RC Lelystad, The Netherlands.
  • Schuurman T; Animal Sciences Group, Wageningen University and Research, 6708 WD Wageningen, Lelystad, The Netherlands.
  • Griffioen AW; Angiogenesis Laboratory, Department of Medical Oncology, Vrije Universiteit Medical Center, 1081 HZ Amsterdam, The Netherlands; p.timmerman@pepscan.com aw.griffioen@vumc.nl.
  • Timmerman P; Pepscan Therapeutics B.V., 8243 RC Lelystad, The Netherlands; p.timmerman@pepscan.com aw.griffioen@vumc.nl.
Proc Natl Acad Sci U S A ; 113(44): 12532-12537, 2016 11 01.
Article in En | MEDLINE | ID: mdl-27791128
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Full text: 1 Collection: 01-internacional Health context: 2_ODS3 Database: MEDLINE Main subject: Peptides / Vaccination / Colonic Neoplasms / Vascular Endothelial Growth Factor A / Bevacizumab Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Proc Natl Acad Sci U S A Year: 2016 Document type: Article
Fulltext
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PubMed Links
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Full text: 1 Collection: 01-internacional Health context: 2_ODS3 Database: MEDLINE Main subject: Peptides / Vaccination / Colonic Neoplasms / Vascular Endothelial Growth Factor A / Bevacizumab Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Proc Natl Acad Sci U S A Year: 2016 Document type: Article