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Strong antitumor synergy between DNA crosslinking and HSP90 inhibition causes massive premitotic DNA fragmentation in ovarian cancer cells.
Kramer, Daniela; Stark, Nadine; Schulz-Heddergott, Ramona; Erytch, Norman; Edmunds, Shelley; Roßmann, Laura; Bastians, Holger; Concin, Nicole; Moll, Ute M; Dobbelstein, Matthias.
Affiliation
  • Kramer D; Institute of Molecular Oncology, Göttingen Center of Molecular Biosciences (GZMB), University Medical Center Göttingen, Göttingen D-37077, Germany.
  • Stark N; Institute of Molecular Oncology, Göttingen Center of Molecular Biosciences (GZMB), University Medical Center Göttingen, Göttingen D-37077, Germany.
  • Schulz-Heddergott R; Institute of Molecular Oncology, Göttingen Center of Molecular Biosciences (GZMB), University Medical Center Göttingen, Göttingen D-37077, Germany.
  • Erytch N; Institute of Molecular Oncology, Göttingen Center of Molecular Biosciences (GZMB), University Medical Center Göttingen, Göttingen D-37077, Germany.
  • Edmunds S; Institute of Molecular Oncology, Göttingen Center of Molecular Biosciences (GZMB), University Medical Center Göttingen, Göttingen D-37077, Germany.
  • Roßmann L; Institute of Molecular Oncology, Göttingen Center of Molecular Biosciences (GZMB), University Medical Center Göttingen, Göttingen D-37077, Germany.
  • Bastians H; Institute of Molecular Oncology, Göttingen Center of Molecular Biosciences (GZMB), University Medical Center Göttingen, Göttingen D-37077, Germany.
  • Concin N; Department of Obstetrics and Gynaecology, Medical University of Innsbruck, Innsbruck, Austria.
  • Moll UM; Institute of Molecular Oncology, Göttingen Center of Molecular Biosciences (GZMB), University Medical Center Göttingen, Göttingen D-37077, Germany.
  • Dobbelstein M; Department of Pathology, School of Medicine, Stony Brook University, Stony Brook, NY 11794, USA.
Cell Death Differ ; 24(2): 300-316, 2017 02.
Article in En | MEDLINE | ID: mdl-27834954
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Full text: 1 Collection: 01-internacional Health context: 6_ODS3_enfermedades_notrasmisibles Database: MEDLINE Main subject: DNA Damage / HSP90 Heat-Shock Proteins / DNA Fragmentation / Antineoplastic Agents Type of study: Etiology_studies / Prognostic_studies Limits: Animals / Female / Humans Language: En Journal: Cell Death Differ Year: 2017 Document type: Article
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Full text: 1 Collection: 01-internacional Health context: 6_ODS3_enfermedades_notrasmisibles Database: MEDLINE Main subject: DNA Damage / HSP90 Heat-Shock Proteins / DNA Fragmentation / Antineoplastic Agents Type of study: Etiology_studies / Prognostic_studies Limits: Animals / Female / Humans Language: En Journal: Cell Death Differ Year: 2017 Document type: Article