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InterPro in 2017-beyond protein family and domain annotations.
Finn, Robert D; Attwood, Teresa K; Babbitt, Patricia C; Bateman, Alex; Bork, Peer; Bridge, Alan J; Chang, Hsin-Yu; Dosztányi, Zsuzsanna; El-Gebali, Sara; Fraser, Matthew; Gough, Julian; Haft, David; Holliday, Gemma L; Huang, Hongzhan; Huang, Xiaosong; Letunic, Ivica; Lopez, Rodrigo; Lu, Shennan; Marchler-Bauer, Aron; Mi, Huaiyu; Mistry, Jaina; Natale, Darren A; Necci, Marco; Nuka, Gift; Orengo, Christine A; Park, Youngmi; Pesseat, Sebastien; Piovesan, Damiano; Potter, Simon C; Rawlings, Neil D; Redaschi, Nicole; Richardson, Lorna; Rivoire, Catherine; Sangrador-Vegas, Amaia; Sigrist, Christian; Sillitoe, Ian; Smithers, Ben; Squizzato, Silvano; Sutton, Granger; Thanki, Narmada; Thomas, Paul D; Tosatto, Silvio C E; Wu, Cathy H; Xenarios, Ioannis; Yeh, Lai-Su; Young, Siew-Yit; Mitchell, Alex L.
Affiliation
  • Finn RD; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK rdf@ebi.ac.uk.
  • Attwood TK; School of Computer Science, University of Manchester, UK.
  • Babbitt PC; Department of Bioengineering & Therapeutic Sciences, University of California, San Francisco, CA 94143, USA.
  • Bateman A; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
  • Bork P; European Molecular Biology Laboratory, Biocomputing, Meyerhofstasse 1, 69117 Heidelberg, Germany.
  • Bridge AJ; Swiss-Prot Group, SIB Swiss Institute of Bioinformatics, CMU, 1 rue Michel-Servet, CH-1211 Geneva 4, Switzerland.
  • Chang HY; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
  • Dosztányi Z; MTA-ELTE Lendület Bioinformatics Research Group, Department of Biochemistry, Eötvös Loránd University, Pázmány Péter sétány 1/c, Budapest, Hungary.
  • El-Gebali S; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
  • Fraser M; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
  • Gough J; Computer Science department, University of Bristol, Woodland Road, Bristol BS8 1UB, UK.
  • Haft D; Bioinformatics Department, J. Craig Venter Institute, 9714 Medical Center Drive, Rockville, MD 20850, USA.
  • Holliday GL; Department of Bioengineering & Therapeutic Sciences, University of California, San Francisco, CA 94143, USA.
  • Huang H; Center for Bioinformatics and Computational Biology, University of Delaware, Newark, DE 19711, USA.
  • Huang X; Division of Bioinformatics, Department of Preventive Medicine, University of Southern California, Los Angeles, CA 90033, USA.
  • Letunic I; Biobyte Solutions GmbH, Bothestr. 142, 69126 Heidelberg, Germany.
  • Lopez R; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
  • Lu S; National Center for Biotechnology Information, National Library of Medicine, NIH Bldg, 38A, 8600 Rockville Pike, Bethesda, MD 20894, USA.
  • Marchler-Bauer A; National Center for Biotechnology Information, National Library of Medicine, NIH Bldg, 38A, 8600 Rockville Pike, Bethesda, MD 20894, USA.
  • Mi H; Division of Bioinformatics, Department of Preventive Medicine, University of Southern California, Los Angeles, CA 90033, USA.
  • Mistry J; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
  • Natale DA; Georgetown University Medical Center, 3300 Whitehaven St, NW, Washington, DC 20007, USA.
  • Necci M; Department of Biomedical Sciences and CRIBI Biotech Center, University of Padua, via U. Bassi 58/b, 35131 Padua, Italy.
  • Nuka G; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
  • Orengo CA; Structural and Molecular Biology, University College London, Darwin Building, London WC1E 6BT, UK.
  • Park Y; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
  • Pesseat S; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
  • Piovesan D; Department of Biomedical Sciences and CRIBI Biotech Center, University of Padua, via U. Bassi 58/b, 35131 Padua, Italy.
  • Potter SC; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
  • Rawlings ND; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
  • Redaschi N; Swiss-Prot Group, SIB Swiss Institute of Bioinformatics, CMU, 1 rue Michel-Servet, CH-1211 Geneva 4, Switzerland.
  • Richardson L; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
  • Rivoire C; Swiss-Prot Group, SIB Swiss Institute of Bioinformatics, CMU, 1 rue Michel-Servet, CH-1211 Geneva 4, Switzerland.
  • Sangrador-Vegas A; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
  • Sigrist C; Swiss-Prot Group, SIB Swiss Institute of Bioinformatics, CMU, 1 rue Michel-Servet, CH-1211 Geneva 4, Switzerland.
  • Sillitoe I; Structural and Molecular Biology, University College London, Darwin Building, London WC1E 6BT, UK.
  • Smithers B; Computer Science department, University of Bristol, Woodland Road, Bristol BS8 1UB, UK.
  • Squizzato S; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
  • Sutton G; Bioinformatics Department, J. Craig Venter Institute, 9714 Medical Center Drive, Rockville, MD 20850, USA.
  • Thanki N; National Center for Biotechnology Information, National Library of Medicine, NIH Bldg, 38A, 8600 Rockville Pike, Bethesda, MD 20894, USA.
  • Thomas PD; Division of Bioinformatics, Department of Preventive Medicine, University of Southern California, Los Angeles, CA 90033, USA.
  • Tosatto SC; Department of Biomedical Sciences and CRIBI Biotech Center, University of Padua, via U. Bassi 58/b, 35131 Padua, Italy.
  • Wu CH; CNR Institute of Neuroscience, via U. Bassi 58/b, 35131 Padua, Italy.
  • Xenarios I; Center for Bioinformatics and Computational Biology, University of Delaware, Newark, DE 19711, USA.
  • Yeh LS; Swiss-Prot Group, SIB Swiss Institute of Bioinformatics, CMU, 1 rue Michel-Servet, CH-1211 Geneva 4, Switzerland.
  • Young SY; Georgetown University Medical Center, 3300 Whitehaven St, NW, Washington, DC 20007, USA.
  • Mitchell AL; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
Nucleic Acids Res ; 45(D1): D190-D199, 2017 01 04.
Article in En | MEDLINE | ID: mdl-27899635
ABSTRACT
InterPro (http//www.ebi.ac.uk/interpro/) is a freely available database used to classify protein sequences into families and to predict the presence of important domains and sites. InterProScan is the underlying software that allows both protein and nucleic acid sequences to be searched against InterPro's predictive models, which are provided by its member databases. Here, we report recent developments with InterPro and its associated software, including the addition of two new databases (SFLD and CDD), and the functionality to include residue-level annotation and prediction of intrinsic disorder. These developments enrich the annotations provided by InterPro, increase the overall number of residues annotated and allow more specific functional inferences.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Software / Computational Biology / Databases, Protein / Protein Interaction Domains and Motifs Type of study: Prognostic_studies Limits: Humans Language: En Journal: Nucleic Acids Res Year: 2017 Document type: Article
Fulltext
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Software / Computational Biology / Databases, Protein / Protein Interaction Domains and Motifs Type of study: Prognostic_studies Limits: Humans Language: En Journal: Nucleic Acids Res Year: 2017 Document type: Article