Effects of Anti-CD206 Antibodies on Macrophage Functions in Male CBF1 Mice with Lipidemia.

Lykov, A P; Korolenko, T A; Sakhno, L V; Poveshchenko, O V; Bondarenko, N A; Surovtseva, M A; Goncharova, N V

Lykov, A P; Korolenko, T A; Sakhno, L V; Poveshchenko, O V; Bondarenko, N A; Surovtseva, M A; Goncharova, N V.

Affiliation

Lykov AP; Research Institute of Clinical and Experimental Lymphology, Novosibirsk, Russia. aplykov2@mail.ru.
Korolenko TA; Research Institute of Physiology and Fundamental Medicine, Novosibirsk, Russia.
Sakhno LV; Institute of Fundamental and Clinical Immunology, Novosibirsk, Russia.
Poveshchenko OV; Research Institute of Clinical and Experimental Lymphology, Novosibirsk, Russia.
Bondarenko NA; Research Institute of Clinical and Experimental Lymphology, Novosibirsk, Russia.
Surovtseva MA; Research Institute of Clinical and Experimental Lymphology, Novosibirsk, Russia.
Goncharova NV; Research Institute of Physiology and Fundamental Medicine, Novosibirsk, Russia.

Bull Exp Biol Med ; 162(2): 237-239, 2016 Dec.

Article in En | MEDLINE | ID: mdl-27909959

ABSTRACT

ABSTRACT

The effects of anti-CD208 antibodies (mannose receptor) on functional characteristics of peritoneal macrophages were studied in intact mice and mice with lipidemia induced by poloxamer-407. Lipidemia was associated with suppression of phagocytosis and increase in spontaneous proliferative potential and NO production by macrophages. Anti-CD206 antibodies suppressed NO production by macrophages in mice with lipidemia.

Subject(s)

Antibodies/pharmacology; Hyperlipidemias/immunology; Lectins, C-Type/antagonists & inhibitors; Macrophages, Peritoneal/drug effects; Mannose-Binding Lectins/antagonists & inhibitors; Phagocytosis/drug effects; Receptors, Cell Surface/antagonists & inhibitors; Animals; Cell Proliferation/drug effects; Erythrocytes/immunology; Gene Expression; Hyperlipidemias/chemically induced; Hyperlipidemias/genetics; Hyperlipidemias/pathology; Lectins, C-Type/genetics; Lectins, C-Type/immunology; Lipopolysaccharides/pharmacology; Macrophages, Peritoneal/immunology; Macrophages, Peritoneal/pathology; Male; Mannose Receptor; Mannose-Binding Lectins/genetics; Mannose-Binding Lectins/immunology; Mice; Nitric Oxide/biosynthesis; Poloxamer; Primary Cell Culture; Reactive Oxygen Species/immunology; Reactive Oxygen Species/metabolism; Receptors, Cell Surface/genetics; Receptors, Cell Surface/immunology; Sheep

Key words

P-407; lipidemia; macrophages; phagocytosis; reactive oxygen species

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Collection: 01-internacional Database: MEDLINE Main subject: Phagocytosis / Macrophages, Peritoneal / Receptors, Cell Surface / Lectins, C-Type / Mannose-Binding Lectins / Hyperlipidemias / Antibodies Limits: Animals Language: En Journal: Bull Exp Biol Med Year: 2016 Document type: Article

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