Dabigatran overdose: a case report of acute hepatitis. Extracorporeal treatment.
Int J Hematol
; 105(4): 532-535, 2017 Apr.
Article
in En
| MEDLINE
| ID: mdl-27910004
ABSTRACT
Dabigatran is an oral, direct thrombin inhibitor approved by international regulatory agencies for stroke prevention in patients with paroxysmal or persistent non-rheumatic atrial fibrillation (AF). The benefits of dabigatran are widely described, but its use in the geriatric population is not without risk. Chronic kidney disease is a common comorbidity with AF, and thus frequent checks of renal function in elderly patients are recommended. We report a case of dabigatran intoxication in an elderly man affected by heart failure and worsening renal function, who developed acute hepatitis and coma, which was successfully treated with continuous veno-venous hemodiafiltration. Although extracorporeal therapy has been suggested as a strategy for clearing dabigatran during acute bleeding, this approach may be useful in other dabigatran-related, life-threatening conditions, such as that described in this report.
Key words
Full text:
1
Collection:
01-internacional
Health context:
1_ASSA2030
/
2_ODS3
Database:
MEDLINE
Main subject:
Hemodiafiltration
/
Drug Overdose
/
Dabigatran
/
Hepatitis
Type of study:
Etiology_studies
Limits:
Aged
/
Humans
/
Male
Language:
En
Journal:
Int J Hematol
Year:
2017
Document type:
Article