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[RET pro-oncogene and medullary thyroid carcinoma].
Wang, Y; Du, L L; Hou, S H; Han, C Z; Zhao, X W; Wang, W G; Xu, X Q; Jing, J X.
Affiliation
  • Wang Y; Department of Etiology and Biomarker Detection, Shanxi Cancer Institute, Taiyuan 030013, China.
  • Du LL; Department of Etiology and Biomarker Detection, Shanxi Cancer Institute, Taiyuan 030013, China.
  • Hou SH; Department of Anal and Colotectal Surgery, Shanxi Cancer Institute, Taiyuan 030013, China.
  • Han CZ; Department of Etiology and Biomarker Detection, Shanxi Cancer Institute, Taiyuan 030013, China.
  • Zhao XW; Department of Etiology and Biomarker Detection, Shanxi Cancer Institute, Taiyuan 030013, China.
  • Wang WG; Department of Etiology and Biomarker Detection, Shanxi Cancer Institute, Taiyuan 030013, China.
  • Xu XQ; Department of Etiology and Biomarker Detection, Shanxi Cancer Institute, Taiyuan 030013, China.
  • Jing JX; Department of Etiology and Biomarker Detection, Shanxi Cancer Institute, Taiyuan 030013, China.
Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi ; 51(11): 873-876, 2016 Nov 07.
Article in Zh | MEDLINE | ID: mdl-27938622
ABSTRACT
Medullary thyroid carcinoma (MTC) originats from the parafollicular C cells of the thyroid, which is one of the most aggressive forms of thyroid malignancy with the poor prognosis. Hereditary MTC has multiple endocrine neoplasia types 1, 2A and 2B. The mutation of RET proto-oncogene has been identified as the main cause of MTC, and all mutations locate among the exons 5, 8, 10, 11, 13, 14, 15, and 16. Mutation analysis of the RET may provide a theoretical basis for the prevention, diagnosis and treatment of MTC.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Thyroid Neoplasms / Carcinoma, Neuroendocrine / Proto-Oncogene Proteins c-ret / Mutation Limits: Humans Language: Zh Journal: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi Year: 2016 Document type: Article
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Thyroid Neoplasms / Carcinoma, Neuroendocrine / Proto-Oncogene Proteins c-ret / Mutation Limits: Humans Language: Zh Journal: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi Year: 2016 Document type: Article