DOPAL derived alpha-synuclein oligomers impair synaptic vesicles physiological function.

Plotegher, N; Berti, G; Ferrari, E; Tessari, I; Zanetti, M; Lunelli, L; Greggio, E; Bisaglia, M; Veronesi, M; Girotto, S; Dalla Serra, M; Perego, C; Casella, L; Bubacco, L

Plotegher, N; Berti, G; Ferrari, E; Tessari, I; Zanetti, M; Lunelli, L; Greggio, E; Bisaglia, M; Veronesi, M; Girotto, S; Dalla Serra, M; Perego, C; Casella, L; Bubacco, L.

Affiliation

Plotegher N; Department of Biology, University of Padova, Italy.
Berti G; Department of Biology, University of Padova, Italy.
Ferrari E; Department of Chemistry, University of Pavia, Italy.
Tessari I; Institute of Biomedical Technologies, National Research Council of Italy, Segrate (Milan), Italy.
Zanetti M; Department of Biology, University of Padova, Italy.
Lunelli L; Institute of Biophysics, National Research Council of Italy, Trento, Italy.
Greggio E; Laboratory of Biomolecular Sequence and Structure Analysis for Health, Bruno Kessler Foundation, Trento, Italy.
Bisaglia M; Institute of Biophysics, National Research Council of Italy, Trento, Italy.
Veronesi M; Laboratory of Biomolecular Sequence and Structure Analysis for Health, Bruno Kessler Foundation, Trento, Italy.
Girotto S; Department of Biology, University of Padova, Italy.
Dalla Serra M; Department of Biology, University of Padova, Italy.
Perego C; Department of Drug Discovery and Development, Istituto Italiano di Tecnologia, Genova, Italy.
Casella L; Department of Drug Discovery and Development, Istituto Italiano di Tecnologia, Genova, Italy.
Bubacco L; Institute of Biophysics, National Research Council of Italy, Trento, Italy.

Sci Rep ; 7: 40699, 2017 01 13.

Article in En | MEDLINE | ID: mdl-28084443

Subject(s)

3,4-Dihydroxyphenylacetic Acid/analogs & derivatives; Protein Multimerization/drug effects; Synaptic Vesicles/drug effects; Synaptic Vesicles/metabolism; alpha-Synuclein/metabolism; 3,4-Dihydroxyphenylacetic Acid/pharmacology; Animals; Biological Transport/drug effects; Cell Line; Cell Membrane/metabolism; Humans; Magnetic Resonance Spectroscopy; Mice; Neurons/drug effects; Neurons/metabolism; Neurons/ultrastructure; Permeability; Protein Aggregates; Protein Aggregation, Pathological; Protein Binding; Tandem Mass Spectrometry; alpha-Synuclein/chemistry

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Synaptic Vesicles / 3,4-Dihydroxyphenylacetic Acid / Alpha-Synuclein / Protein Multimerization Limits: Animals / Humans Language: En Journal: Sci Rep Year: 2017 Document type: Article

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