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THZ1 targeting CDK7 suppresses STAT transcriptional activity and sensitizes T-cell lymphomas to BCL2 inhibitors.
Cayrol, Florencia; Praditsuktavorn, Pannee; Fernando, Tharu M; Kwiatkowski, Nicholas; Marullo, Rosella; Calvo-Vidal, M Nieves; Phillip, Jude; Pera, Benet; Yang, Shao Ning; Takpradit, Kaipol; Roman, Lidia; Gaudiano, Marcello; Crescenzo, Ramona; Ruan, Jia; Inghirami, Giorgio; Zhang, Tinghu; Cremaschi, Graciela; Gray, Nathanael S; Cerchietti, Leandro.
Affiliation
  • Cayrol F; Department of Medicine, Hematology and Oncology Division, Weill Cornell Medicine, New York, New York 10065, USA.
  • Praditsuktavorn P; Neuroimmunomodulation and Molecular Oncology Department, Institute for Biomedical Research (BIOMED), National Research Council of Argentina (CONICET), Catholic University of Argentina (UCA), C1107AFB Ciudad Autonoma de Buenos Aires, Argentina.
  • Fernando TM; Department of Medicine, Hematology and Oncology Division, Weill Cornell Medicine, New York, New York 10065, USA.
  • Kwiatkowski N; Department of Medicine, Hematology and Oncology Division, Weill Cornell Medicine, New York, New York 10065, USA.
  • Marullo R; Department of Cancer Biology, Dana-Farber Cancer Institute, Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA.
  • Calvo-Vidal MN; Department of Medicine, Hematology and Oncology Division, Weill Cornell Medicine, New York, New York 10065, USA.
  • Phillip J; Department of Medicine, Hematology and Oncology Division, Weill Cornell Medicine, New York, New York 10065, USA.
  • Pera B; Department of Medicine, Hematology and Oncology Division, Weill Cornell Medicine, New York, New York 10065, USA.
  • Yang SN; Department of Medicine, Hematology and Oncology Division, Weill Cornell Medicine, New York, New York 10065, USA.
  • Takpradit K; Department of Medicine, Hematology and Oncology Division, Weill Cornell Medicine, New York, New York 10065, USA.
  • Roman L; Department of Medicine, Hematology and Oncology Division, Weill Cornell Medicine, New York, New York 10065, USA.
  • Gaudiano M; Department of Medicine, Hematology and Oncology Division, Weill Cornell Medicine, New York, New York 10065, USA.
  • Crescenzo R; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, New York 10065, USA.
  • Ruan J; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, New York 10065, USA.
  • Inghirami G; Department of Medicine, Hematology and Oncology Division, Weill Cornell Medicine, New York, New York 10065, USA.
  • Zhang T; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, New York 10065, USA.
  • Cremaschi G; Department of Cancer Biology, Dana-Farber Cancer Institute, Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA.
  • Gray NS; Neuroimmunomodulation and Molecular Oncology Department, Institute for Biomedical Research (BIOMED), National Research Council of Argentina (CONICET), Catholic University of Argentina (UCA), C1107AFB Ciudad Autonoma de Buenos Aires, Argentina.
  • Cerchietti L; Department of Cancer Biology, Dana-Farber Cancer Institute, Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA.
Nat Commun ; 8: 14290, 2017 01 30.
Article in En | MEDLINE | ID: mdl-28134252
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Full text: 1 Collection: 01-internacional Health context: 6_ODS3_enfermedades_notrasmisibles Database: MEDLINE Main subject: Antineoplastic Combined Chemotherapy Protocols / Gene Expression Regulation, Neoplastic / Lymphoma, T-Cell / Cyclin-Dependent Kinases / Proto-Oncogene Proteins c-bcl-2 Type of study: Prognostic_studies Language: En Journal: Nat Commun Year: 2017 Document type: Article
Fulltext
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Full text: 1 Collection: 01-internacional Health context: 6_ODS3_enfermedades_notrasmisibles Database: MEDLINE Main subject: Antineoplastic Combined Chemotherapy Protocols / Gene Expression Regulation, Neoplastic / Lymphoma, T-Cell / Cyclin-Dependent Kinases / Proto-Oncogene Proteins c-bcl-2 Type of study: Prognostic_studies Language: En Journal: Nat Commun Year: 2017 Document type: Article