Macrophages confer survival signals via CCR1-dependent translational MCL-1 induction in chronic lymphocytic leukemia.

van Attekum, M H A; Terpstra, S; Slinger, E; von Lindern, M; Moerland, P D; Jongejan, A; Kater, A P; Eldering, E

van Attekum, M H A; Terpstra, S; Slinger, E; von Lindern, M; Moerland, P D; Jongejan, A; Kater, A P; Eldering, E.

Affiliation

van Attekum MHA; Department of Hematology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
Terpstra S; Department of Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
Slinger E; Department of Hematology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
von Lindern M; Department of Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
Moerland PD; Department of Hematology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
Jongejan A; Department of Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
Kater AP; Department of Hematopoiesis, Sanquin Research, Amsterdam, The Netherlands.
Eldering E; Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

Oncogene ; 36(26): 3651-3660, 2017 06 29.

Article in En | MEDLINE | ID: mdl-28192408

Subject(s)

Leukemia, Lymphocytic, Chronic, B-Cell/pathology; Macrophages/pathology; Myeloid Cell Leukemia Sequence 1 Protein/metabolism; Receptors, CCR1/metabolism; Animals; Apoptosis/physiology; CD40 Ligand/genetics; CD40 Ligand/metabolism; Cell Line, Tumor; Cell Survival/physiology; Down-Regulation; Humans; Leukemia, Lymphocytic, Chronic, B-Cell/genetics; Leukemia, Lymphocytic, Chronic, B-Cell/metabolism; Macrophages/metabolism; Mice; Myeloid Cell Leukemia Sequence 1 Protein/genetics; NIH 3T3 Cells; Receptors, CCR1/genetics; Signal Transduction; T-Lymphocytes/metabolism; T-Lymphocytes/pathology; Transfection

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Leukemia, Lymphocytic, Chronic, B-Cell / Receptors, CCR1 / Myeloid Cell Leukemia Sequence 1 Protein / Macrophages Limits: Animals / Humans Language: En Journal: Oncogene Year: 2017 Document type: Article

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