Development of Precision Small-Molecule Proneurotrophic Therapies for Neurodegenerative Diseases.

Janssens, J; Lu, D; Ni, B; Chadwick, W; Siddiqui, S; Azmi, A; Etienne, H; Jushaj, A; van Gastel, J; Martin, B; Maudsley, S

Janssens, J; Lu, D; Ni, B; Chadwick, W; Siddiqui, S; Azmi, A; Etienne, H; Jushaj, A; van Gastel, J; Martin, B; Maudsley, S.

Affiliation

Janssens J; Translational Neurobiology Group, University of Antwerp, Antwerpen, Belgium.
Lu D; Receptor Pharmacology Unit, National Institute on Aging, National Institutes of Health, Baltimore MD United States.
Ni B; Receptor Pharmacology Unit, National Institute on Aging, National Institutes of Health, Baltimore MD United States.
Chadwick W; Receptor Pharmacology Unit, National Institute on Aging, National Institutes of Health, Baltimore MD United States.
Siddiqui S; Receptor Pharmacology Unit, National Institute on Aging, National Institutes of Health, Baltimore MD United States.
Azmi A; Translational Neurobiology Group, University of Antwerp, Antwerpen, Belgium.
Etienne H; Translational Neurobiology Group, University of Antwerp, Antwerpen, Belgium.
Jushaj A; Translational Neurobiology Group, University of Antwerp, Antwerpen, Belgium.
van Gastel J; Translational Neurobiology Group, University of Antwerp, Antwerpen, Belgium.
Martin B; Metabolism Unit, National Institute on Aging, National Institutes of Health, Baltimore MD United States.
Maudsley S; Translational Neurobiology Group, University of Antwerp, Antwerpen, Belgium; Receptor Pharmacology Unit, National Institute on Aging, National Institutes of Health, Baltimore MD United States. Electronic address: stuart.maudsley@molgen.vib-ua.be.

Vitam Horm ; 104: 263-311, 2017.

Article in En | MEDLINE | ID: mdl-28215298

Subject(s)

Drug Design; Drugs, Investigational/therapeutic use; Nerve Growth Factors/therapeutic use; Neurodegenerative Diseases/drug therapy; Protein Precursors/therapeutic use; Receptors, Nerve Growth Factor/agonists; Animals; Central Nervous System/drug effects; Central Nervous System/growth & development; Central Nervous System/metabolism; Cognitive Dysfunction/drug therapy; Cognitive Dysfunction/metabolism; Cognitive Dysfunction/prevention & control; Dimerization; Drugs, Investigational/chemistry; Humans; Ligands; Molecular Targeted Therapy; Nerve Growth Factors/chemistry; Nerve Growth Factors/metabolism; Neurodegenerative Diseases/metabolism; Neuronal Plasticity/drug effects; Neurons/drug effects; Neurons/metabolism; Neuroprotection/drug effects; Neuroprotective Agents/chemistry; Neuroprotective Agents/metabolism; Neuroprotective Agents/therapeutic use; Nootropic Agents/chemistry; Nootropic Agents/metabolism; Nootropic Agents/therapeutic use; Protein Precursors/chemistry; Protein Precursors/metabolism; Receptors, Nerve Growth Factor/metabolism; Signal Transduction/drug effects

Key words

Aging; Dementia; Neurodegeneration; Neurotrophin; Precision; Receptor; Tyrosine kinase

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Full text: 1 Collection: 01-internacional Health context: 1_ASSA2030 Database: MEDLINE Main subject: Protein Precursors / Drug Design / Drugs, Investigational / Receptors, Nerve Growth Factor / Neurodegenerative Diseases / Nerve Growth Factors Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Vitam Horm Year: 2017 Document type: Article

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