Synthesis of dual-action parthenolide prodrugs as potent anticancer agents.

Taleghani, Akram; Nasseri, Mohammad Ali; Iranshahi, Mehrdad

Taleghani, Akram; Nasseri, Mohammad Ali; Iranshahi, Mehrdad.

Affiliation

Taleghani A; Department of Chemistry, Faculty of Science, University of Birjand, P.O. Box 97175-615, Birjand, Iran.
Nasseri MA; Department of Chemistry, Faculty of Science, University of Birjand, P.O. Box 97175-615, Birjand, Iran.
Iranshahi M; Department of Pharmcognosy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran; Biotechnology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address: Iranshahim@mums.ac.ir.

Bioorg Chem ; 71: 128-134, 2017 04.

Article in En | MEDLINE | ID: mdl-28215600

Subject(s)

Antineoplastic Agents/chemistry; Antineoplastic Agents/pharmacology; Apoptosis/drug effects; Prodrugs/chemistry; Prodrugs/pharmacology; Sesquiterpenes/chemistry; Sesquiterpenes/pharmacology; Antineoplastic Agents/chemical synthesis; Catalysis; Cell Line, Tumor; Chemistry Techniques, Synthetic; Cytarabine/analogs & derivatives; Cytarabine/chemical synthesis; Cytarabine/pharmacology; Humans; Lactones/chemistry; Melphalan/analogs & derivatives; Melphalan/chemical synthesis; Melphalan/pharmacology; Neoplasms/drug therapy; Prodrugs/chemical synthesis; Sesquiterpenes/chemical synthesis

Key words

Cytarabine; Cytotoxic activity; Melphalan; Parthenolide; aza-Michael addition

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sesquiterpenes / Prodrugs / Apoptosis / Antineoplastic Agents Limits: Humans Language: En Journal: Bioorg Chem Year: 2017 Document type: Article

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