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Discovery of orally active hepatoselective glucokinase activators for treatment of Type II Diabetes Mellitus.
Xu, Jiayi; Lin, Songnian; Myers, Robert W; Trujillo, Maria E; Pachanski, Michele J; Malkani, Sunita; Chen, Hsuan-Shen; Chen, Zhesheng; Campbell, Brian; Eiermann, George J; Elowe, Nadine; Farrer, Brian T; Feng, Wen; Fu, Qinghong; Kats-Kagan, Roman; Kavana, Michael; McMasters, Daniel R; Mitra, Kaushik; Tong, Xinchun; Xu, Libo; Zhang, Fengqi; Zhang, Rui; Addona, George H; Berger, Joel P; Zhang, Bei; Parmee, Emma R.
Affiliation
  • Xu J; Discovery, Preclinical and Early Development, Merck & Co., Inc., 2015 Galloping Hill Rd, Kenilworth, NJ 07033, USA. Electronic address: Jiayi_xu@merck.com.
  • Lin S; Discovery, Preclinical and Early Development, Merck & Co., Inc., 2015 Galloping Hill Rd, Kenilworth, NJ 07033, USA. Electronic address: songnian_lin@merck.com.
  • Myers RW; Discovery, Preclinical and Early Development, Merck & Co., Inc., 2015 Galloping Hill Rd, Kenilworth, NJ 07033, USA.
  • Trujillo ME; Discovery, Preclinical and Early Development, Merck & Co., Inc., 2015 Galloping Hill Rd, Kenilworth, NJ 07033, USA.
  • Pachanski MJ; Discovery, Preclinical and Early Development, Merck & Co., Inc., 2015 Galloping Hill Rd, Kenilworth, NJ 07033, USA.
  • Malkani S; Discovery, Preclinical and Early Development, Merck & Co., Inc., 2015 Galloping Hill Rd, Kenilworth, NJ 07033, USA.
  • Chen HS; Discovery, Preclinical and Early Development, Merck & Co., Inc., 2015 Galloping Hill Rd, Kenilworth, NJ 07033, USA.
  • Chen Z; Discovery, Preclinical and Early Development, Merck & Co., Inc., 2015 Galloping Hill Rd, Kenilworth, NJ 07033, USA.
  • Campbell B; Discovery, Preclinical and Early Development, Merck & Co., Inc., 2015 Galloping Hill Rd, Kenilworth, NJ 07033, USA.
  • Eiermann GJ; Discovery, Preclinical and Early Development, Merck & Co., Inc., 2015 Galloping Hill Rd, Kenilworth, NJ 07033, USA.
  • Elowe N; Discovery, Preclinical and Early Development, Merck & Co., Inc., 2015 Galloping Hill Rd, Kenilworth, NJ 07033, USA.
  • Farrer BT; Discovery, Preclinical and Early Development, Merck & Co., Inc., 2015 Galloping Hill Rd, Kenilworth, NJ 07033, USA.
  • Feng W; Discovery, Preclinical and Early Development, Merck & Co., Inc., 2015 Galloping Hill Rd, Kenilworth, NJ 07033, USA.
  • Fu Q; Discovery, Preclinical and Early Development, Merck & Co., Inc., 2015 Galloping Hill Rd, Kenilworth, NJ 07033, USA.
  • Kats-Kagan R; Discovery, Preclinical and Early Development, Merck & Co., Inc., 2015 Galloping Hill Rd, Kenilworth, NJ 07033, USA.
  • Kavana M; Discovery, Preclinical and Early Development, Merck & Co., Inc., 2015 Galloping Hill Rd, Kenilworth, NJ 07033, USA.
  • McMasters DR; Discovery, Preclinical and Early Development, Merck & Co., Inc., 2015 Galloping Hill Rd, Kenilworth, NJ 07033, USA.
  • Mitra K; Discovery, Preclinical and Early Development, Merck & Co., Inc., 2015 Galloping Hill Rd, Kenilworth, NJ 07033, USA.
  • Tong X; Discovery, Preclinical and Early Development, Merck & Co., Inc., 2015 Galloping Hill Rd, Kenilworth, NJ 07033, USA.
  • Xu L; Discovery, Preclinical and Early Development, Merck & Co., Inc., 2015 Galloping Hill Rd, Kenilworth, NJ 07033, USA.
  • Zhang F; Discovery, Preclinical and Early Development, Merck & Co., Inc., 2015 Galloping Hill Rd, Kenilworth, NJ 07033, USA.
  • Zhang R; Discovery, Preclinical and Early Development, Merck & Co., Inc., 2015 Galloping Hill Rd, Kenilworth, NJ 07033, USA.
  • Addona GH; Discovery, Preclinical and Early Development, Merck & Co., Inc., 2015 Galloping Hill Rd, Kenilworth, NJ 07033, USA.
  • Berger JP; Discovery, Preclinical and Early Development, Merck & Co., Inc., 2015 Galloping Hill Rd, Kenilworth, NJ 07033, USA.
  • Zhang B; Discovery, Preclinical and Early Development, Merck & Co., Inc., 2015 Galloping Hill Rd, Kenilworth, NJ 07033, USA.
  • Parmee ER; Discovery, Preclinical and Early Development, Merck & Co., Inc., 2015 Galloping Hill Rd, Kenilworth, NJ 07033, USA.
Bioorg Med Chem Lett ; 27(9): 2063-2068, 2017 05 01.
Article in En | MEDLINE | ID: mdl-28284809
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyridines / Enzyme Activators / Diabetes Mellitus, Type 2 / Glucokinase / Hypoglycemic Agents Limits: Animals / Humans Language: En Journal: Bioorg Med Chem Lett Year: 2017 Document type: Article
Fulltext
Print
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyridines / Enzyme Activators / Diabetes Mellitus, Type 2 / Glucokinase / Hypoglycemic Agents Limits: Animals / Humans Language: En Journal: Bioorg Med Chem Lett Year: 2017 Document type: Article