HIV-1 CRF07_BC with a Seven Amino Acid Deletion in the gag p6 Region Dominates in HIV-1-Infected Men Who Have Sex with Men in China.
AIDS Res Hum Retroviruses
; 33(9): 977-983, 2017 Sep.
Article
in En
| MEDLINE
| ID: mdl-28509569
ABSTRACT
We examined sequence variation in the HIV-1 gag p6 region from 27 individuals infected with HIV-1 CRF07_BC. An additional 269 gag p6 sequences of CRF07_BC from the Los Alamos National Laboratory database were also analyzed. A unique deletion of seven amino acid (aa) (p6Δ7) (aa 30-36, PIDKELY, in the HXB2 genome) was observed to exist exclusively in CRF07_BC. Indeed, 54.1% (160/296) of the CRF07_BC sequences contained the p6Δ7 mutation. The prevalence of the p6Δ7 mutation was 37.2% (29/78) and 92.3% (48/52) in CRF07_BC-infected intravenous drug users and men who have sex with men (MSM), respectively. Our results demonstrate that the p6Δ7 mutation dominates in MSM infected by HIV-1 CRF07_BC in China and suggests that this deletion could serve as a useful marker for monitoring HIV-1 evolution and epidemic. In future studies, it will be of interest to determine whether such genotypic variation influences viral replication capacity and disease progression.
Key words
Full text:
1
Collection:
01-internacional
Health context:
2_ODS3
Database:
MEDLINE
Main subject:
Genes, gag
/
HIV Infections
/
HIV-1
/
Sequence Deletion
/
Gag Gene Products, Human Immunodeficiency Virus
/
Amino Acids
Type of study:
Risk_factors_studies
Limits:
Humans
/
Male
Country/Region as subject:
Asia
Language:
En
Journal:
AIDS Res Hum Retroviruses
Year:
2017
Document type:
Article