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Persistent mTORC1 signaling in cell senescence results from defects in amino acid and growth factor sensing.
Carroll, Bernadette; Nelson, Glyn; Rabanal-Ruiz, Yoana; Kucheryavenko, Olena; Dunhill-Turner, Natasha A; Chesterman, Charlotte C; Zahari, Qabil; Zhang, Tong; Conduit, Sarah E; Mitchell, Christina A; Maddocks, Oliver D K; Lovat, Penny; von Zglinicki, Thomas; Korolchuk, Viktor I.
Affiliation
  • Carroll B; Institute for Cell and Molecular Biosciences, Newcastle University, Newcastle upon Tyne, UK bernadette.carroll@ncl.ac.uk.
  • Nelson G; Institute for Cell and Molecular Biosciences, Newcastle University, Newcastle upon Tyne, UK.
  • Rabanal-Ruiz Y; Institute for Cell and Molecular Biosciences, Newcastle University, Newcastle upon Tyne, UK.
  • Kucheryavenko O; Institute for Cell and Molecular Biosciences, Newcastle University, Newcastle upon Tyne, UK.
  • Dunhill-Turner NA; Institute for Cell and Molecular Biosciences, Newcastle University, Newcastle upon Tyne, UK.
  • Chesterman CC; Institute for Cell and Molecular Biosciences, Newcastle University, Newcastle upon Tyne, UK.
  • Zahari Q; Institute for Cell and Molecular Biosciences, Newcastle University, Newcastle upon Tyne, UK.
  • Zhang T; Wolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, University of Glasgow, Glasgow, Scotland, UK.
  • Conduit SE; Cancer Program, Monash Biomedicine Discovery Institute, Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia.
  • Mitchell CA; Cancer Program, Monash Biomedicine Discovery Institute, Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia.
  • Maddocks ODK; Wolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, University of Glasgow, Glasgow, Scotland, UK.
  • Lovat P; Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK.
  • von Zglinicki T; Institute for Cell and Molecular Biosciences, Newcastle University, Newcastle upon Tyne, UK.
  • Korolchuk VI; Institute for Cell and Molecular Biosciences, Newcastle University, Newcastle upon Tyne, UK viktor.korolchuk@ncl.ac.uk.
J Cell Biol ; 216(7): 1949-1957, 2017 07 03.
Article in En | MEDLINE | ID: mdl-28566325
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Signal Transduction / Cellular Senescence / Intercellular Signaling Peptides and Proteins / Multiprotein Complexes / TOR Serine-Threonine Kinases / Fibroblasts / Amino Acids Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: J Cell Biol Year: 2017 Document type: Article
Fulltext
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Signal Transduction / Cellular Senescence / Intercellular Signaling Peptides and Proteins / Multiprotein Complexes / TOR Serine-Threonine Kinases / Fibroblasts / Amino Acids Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: J Cell Biol Year: 2017 Document type: Article