Trichoderpyrone, a Unique Polyketide Hybrid with a Cyclopentenone-Pyrone Skeleton from the Plant Endophytic Fungus Trichoderma gamsii.
J Nat Prod
; 80(6): 1944-1947, 2017 06 23.
Article
in En
| MEDLINE
| ID: mdl-28571311
ABSTRACT
Trichoderpyrone (1), a unique polyketide with a cyclopentenone-pyrone hybrid skeleton, was isolated from the plant endophytic fungus Trichoderma gamsii. The structure of 1 was determined by detailed analysis of NMR data together with comparison of chemical shift values of similar fragments. The relative and absolute configurations were established by NOESY correlations and CD experiment. Trichoderpyrone (1) displayed weak cytotoxic activities against A549, HepG2, and HeLa cancer cell lines. 1 might originate from a hybrid biosynthetic pathway through two nonreduced (NR) polyketide megasynthetases.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Trichoderma
/
Polyketides
Limits:
Humans
Language:
En
Journal:
J Nat Prod
Year:
2017
Document type:
Article