Early childhood infections precede development of beta-cell autoimmunity and type 1 diabetes in children with HLA-conferred disease risk.

Mustonen, N; Siljander, H; Peet, A; Tillmann, V; Härkönen, T; Ilonen, J; Hyöty, H; Knip, M

Mustonen, N; Siljander, H; Peet, A; Tillmann, V; Härkönen, T; Ilonen, J; Hyöty, H; Knip, M.

Affiliation

Mustonen N; Children's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Siljander H; Research Programs Unit, Diabetes and Obesity, University of Helsinki, Helsinki, Finland.
Peet A; Children's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Tillmann V; Research Programs Unit, Diabetes and Obesity, University of Helsinki, Helsinki, Finland.
Härkönen T; Department of Pediatrics, University of Tartu and Tartu University Hospital, Tartu, Estonia.
Ilonen J; Department of Pediatrics, University of Tartu and Tartu University Hospital, Tartu, Estonia.
Hyöty H; Children's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Knip M; Research Programs Unit, Diabetes and Obesity, University of Helsinki, Helsinki, Finland.

Pediatr Diabetes ; 19(2): 293-299, 2018 03.

Article in En | MEDLINE | ID: mdl-28597957

Subject(s)

Autoimmunity; Child Development; Community-Acquired Infections/immunology; Diabetes Mellitus, Type 1/immunology; Insulin-Secreting Cells/immunology; Prediabetic State/immunology; Respiratory Tract Infections/immunology; Cohort Studies; Community-Acquired Infections/blood; Community-Acquired Infections/epidemiology; Community-Acquired Infections/genetics; Diabetes Mellitus, Type 1/blood; Diabetes Mellitus, Type 1/epidemiology; Diabetes Mellitus, Type 1/genetics; Disease Progression; Disease Susceptibility; Estonia/epidemiology; Female; Finland/epidemiology; Follow-Up Studies; Genetic Predisposition to Disease; HLA-DR Antigens/chemistry; HLA-DR Antigens/genetics; Humans; Infant, Newborn; Male; Prediabetic State/blood; Prediabetic State/genetics; Prediabetic State/physiopathology; Prospective Studies; Respiratory Tract Infections/blood; Respiratory Tract Infections/epidemiology; Respiratory Tract Infections/genetics; Risk; Russia/epidemiology

Key words

childhood infections; islet autoimmunity; respiratory tract infections; the hygiene hypothesis; type 1 diabetes

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Prediabetic State / Respiratory Tract Infections / Autoimmunity / Child Development / Community-Acquired Infections / Diabetes Mellitus, Type 1 / Insulin-Secreting Cells Type of study: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Female / Humans / Male / Newborn Country/Region as subject: Asia / Europa Language: En Journal: Pediatr Diabetes Year: 2018 Document type: Article

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