Impact of capillary flow hydrodynamics on carrier-mediated transport of opioid derivatives at the blood-brain barrier, based on pH-dependent Michaelis-Menten and Crone-Renkin analyses.

Yusof, Siti R; Abbott, N Joan; Avdeef, Alex

Yusof, Siti R; Abbott, N Joan; Avdeef, Alex.

Affiliation

Yusof SR; HICoE Centre for Drug Research, Universiti Sains Malaysia, 11800 Minden, Penang, Malaysia.
Abbott NJ; King's College London, Institute of Pharmaceutical Science, Franklin Wilkins Building, 150 Stamford St., London SE1 9NH, UK.
Avdeef A; in-ADME Research, 1732 First Avenue, #102, New York, NY 10128, USA. Electronic address: alex@in-ADME.com.

Eur J Pharm Sci ; 106: 274-286, 2017 Aug 30.

Article in En | MEDLINE | ID: mdl-28614733

Subject(s)

Analgesics, Opioid/pharmacokinetics; Blood-Brain Barrier/metabolism; Naloxone/pharmacokinetics; Oxycodone/pharmacokinetics; Pentazocine/pharmacokinetics; Animals; Biological Transport; Hydrogen-Ion Concentration; Kinetics; Models, Biological; Permeability; Rats

Key words

Blood-brain barrier; Brain permeability-surface area; Rodent in situ brain perfusion; pH-Dependent Crone-Renkin equation; pH-Dependent Michaelis-Menten analysis

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oxycodone / Pentazocine / Blood-Brain Barrier / Analgesics, Opioid / Naloxone Limits: Animals Language: En Journal: Eur J Pharm Sci Year: 2017 Document type: Article

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