S100B: Correlation with Active Vitiligo Depigmentation.
J Invest Dermatol
; 137(7): 1408-1410, 2017 07.
Article
in En
| MEDLINE
| ID: mdl-28647026
ABSTRACT
Vitiligo, the most common depigmenting disorder, is caused by immune destruction of melanocytes by cytotoxic CD8+ T cells. One weakness in vitiligo management is the lack of an assessment method for active depigmentation. Beginning with reports about increased S100B levels in different inflammatory and tissue damage processes, Speeckaert et al. explored correlations between the S100B dynamics and vitiligo activity, identifying high circulating S100B levels in patients with active depigmentation which were strongly correlated with the extent of affected skin surface. These authors have proposed S100B as a potential disease activity marker in vitiligo.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Skin
/
Vitiligo
/
Autoimmunity
/
S100 Calcium Binding Protein beta Subunit
Limits:
Humans
Language:
En
Journal:
J Invest Dermatol
Year:
2017
Document type:
Article