Efficacy of a standardized extract of Matricariae chamomilla L., Melissa officinalis L. and tyndallized Lactobacillus acidophilus (HA122) in infantile colic: An open randomized controlled trial.
Neurogastroenterol Motil
; 29(12)2017 Dec.
Article
in En
| MEDLINE
| ID: mdl-28665038
ABSTRACT
BACKGROUND:
Infant colic (IC) is a prevalent physiological event of infants, which can disrupt the child's home environment. We aimed to investigate the effectiveness of a mixture of Matricariae chamomilla L., Melissa officinalis L. and tyndallized Lactobacillus acidophilus (HA122) compared with Lactobacillus reuteri DSM 17938 and with simethicone for the treatment of IC.METHODS:
A multicenter randomized comparative study was conducted in infants with colic, according to Rome III criteria, who were randomly assigned to receive M. chamomilla L., M. officinalis L. and tyndallized L. acidophilus (HA122) (Colimil® Plus® ; Milte Italia Spa, Milan, Italy) (Group A), L. reuteri DSM 17938 (Group B) and simethicone (Group C). Treatment was given to subjects for 28 days. KEYRESULTS:
One-hundred and seventy-six patients completed the study. Mean daily crying time at day 28 was significantly lower in group A (-44, 95% CI -58 to -30, P<.001) and group B (-35, 95% CI -49 to -20, P<.001) when compared to group C. No significant difference was observed between Group A and Group B (mean difference -9 minutes, 95% CI -23 to +5, P=.205). At day 28, 39 of 57 (68.4%) of infants in Group C responded to the treatment compared with 57 out of 60 patients (95%) of Group A and 51 out of 59 (86.4%) of Group B (P<.001).CONCLUSIONS:
This study suggests that administration of M. chamomilla L., M. officinalis L. and tyndallized L. acidophilus (HA122) and L. reuteri DSM 17938 are significantly more effective than simethicone in IC. CLINICAL TRIAL REGISTRATION ClinicalTrials.gov NCT02708238.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Complementary Therapies
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Plant Extracts
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Colic
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Probiotics
Type of study:
Clinical_trials
Limits:
Female
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Humans
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Infant
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Male
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Newborn
Language:
En
Journal:
Neurogastroenterol Motil
Year:
2017
Document type:
Article