Di-(2-ethylhexyl) phthalate suppresses IL-12p40 production by GM-CSF-dependent macrophages via the PPAR&#945;/TNFAIP3/TRAF6 axis after lipopolysaccharide stimulation.

Yamaguchi, R; Sakamoto, A; Yamamoto, T; Narahara, S; Sugiuchi, H; Hisada, A; Katoh, T; Yamaguchi, Y

Di-(2-ethylhexyl) phthalate suppresses IL-12p40 production by GM-CSF-dependent macrophages via the PPARα/TNFAIP3/TRAF6 axis after lipopolysaccharide stimulation.

Yamaguchi, R; Sakamoto, A; Yamamoto, T; Narahara, S; Sugiuchi, H; Hisada, A; Katoh, T; Yamaguchi, Y.

Affiliation

Yamaguchi R; 1 Department of Public Health, Faculty of Life Sciences, Kumamoto University School of Medicine, Kumamoto, Japan.
Sakamoto A; 2 Graduate School of Medical Science, Kumamoto Health Science University, Kumamoto, Japan.
Yamamoto T; 2 Graduate School of Medical Science, Kumamoto Health Science University, Kumamoto, Japan.
Narahara S; 2 Graduate School of Medical Science, Kumamoto Health Science University, Kumamoto, Japan.
Sugiuchi H; 2 Graduate School of Medical Science, Kumamoto Health Science University, Kumamoto, Japan.
Hisada A; 2 Graduate School of Medical Science, Kumamoto Health Science University, Kumamoto, Japan.
Katoh T; 1 Department of Public Health, Faculty of Life Sciences, Kumamoto University School of Medicine, Kumamoto, Japan.
Yamaguchi Y; 1 Department of Public Health, Faculty of Life Sciences, Kumamoto University School of Medicine, Kumamoto, Japan.

Hum Exp Toxicol ; 37(6): 596-607, 2018 Jun.

Article in En | MEDLINE | ID: mdl-28673093

Subject(s)

Diethylhexyl Phthalate/toxicity; Interleukin-12 Subunit p40/metabolism; Lipopolysaccharides/pharmacology; Macrophages/drug effects; Plasticizers/toxicity; Cells, Cultured; Dual Oxidases/genetics; Granulocyte-Macrophage Colony-Stimulating Factor/pharmacology; Humans; Intracellular Signaling Peptides and Proteins; Macrophages/metabolism; NADPH Oxidases/genetics; PPAR alpha/genetics; PPAR alpha/metabolism; Protein Kinase C/genetics; RNA, Small Interfering/genetics; TNF Receptor-Associated Factor 6/metabolism; Toll-Like Receptor 4/genetics; Tumor Necrosis Factor alpha-Induced Protein 3/genetics; Tumor Necrosis Factor alpha-Induced Protein 3/metabolism

Key words

Di-(2-ethylhexyl) phthalate; granulocyte-macrophage colony-stimulating factor; macrophage; peroxisome proliferatoractivated receptor α; tumor necrosis factor receptorassociated factor 6; tumor necrosis factor αinduced protein 3

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Plasticizers / Lipopolysaccharides / Diethylhexyl Phthalate / Interleukin-12 Subunit p40 / Macrophages Limits: Humans Language: En Journal: Hum Exp Toxicol Year: 2018 Document type: Article

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