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A novel D2O tracer method to quantify RNA turnover as a biomarker of de novo ribosomal biogenesis, in vitro, in animal models, and in human skeletal muscle.
Brook, M S; Wilkinson, D J; Mitchell, W K; Lund, J L; Phillips, B E; Szewczyk, N J; Kainulainen, H; Lensu, S; Koch, L G; Britton, S L; Greenhaff, P L; Smith, K; Atherton, P J.
Affiliation
  • Brook MS; Medical Research Council-Arthritis Research UK Centre for Musculoskeletal Ageing Research, Clinical, Metabolic and Molecular Physiology, University of Nottingham, Royal Derby Hospital Centre, Derby, United Kingdom.
  • Wilkinson DJ; Medical Research Council-Arthritis Research UK Centre for Musculoskeletal Ageing Research, Clinical, Metabolic and Molecular Physiology, University of Nottingham, Royal Derby Hospital Centre, Derby, United Kingdom.
  • Mitchell WK; Medical Research Council-Arthritis Research UK Centre for Musculoskeletal Ageing Research, Clinical, Metabolic and Molecular Physiology, University of Nottingham, Royal Derby Hospital Centre, Derby, United Kingdom.
  • Lund JL; Medical Research Council-Arthritis Research UK Centre for Musculoskeletal Ageing Research, Clinical, Metabolic and Molecular Physiology, University of Nottingham, Royal Derby Hospital Centre, Derby, United Kingdom.
  • Phillips BE; Medical Research Council-Arthritis Research UK Centre for Musculoskeletal Ageing Research, Clinical, Metabolic and Molecular Physiology, University of Nottingham, Royal Derby Hospital Centre, Derby, United Kingdom.
  • Szewczyk NJ; Medical Research Council-Arthritis Research UK Centre for Musculoskeletal Ageing Research, Clinical, Metabolic and Molecular Physiology, University of Nottingham, Royal Derby Hospital Centre, Derby, United Kingdom.
  • Kainulainen H; Department of Biology of Physical Activity, University of Jyväskylä, Jyväskylä, Finland; and.
  • Lensu S; Department of Biology of Physical Activity, University of Jyväskylä, Jyväskylä, Finland; and.
  • Koch LG; Department of Anesthesiology, University of Michigan, Ann Arbor, Michigan.
  • Britton SL; Department of Anesthesiology, University of Michigan, Ann Arbor, Michigan.
  • Greenhaff PL; Medical Research Council-Arthritis Research UK Centre for Musculoskeletal Ageing Research, Clinical, Metabolic and Molecular Physiology, University of Nottingham, Royal Derby Hospital Centre, Derby, United Kingdom.
  • Smith K; Medical Research Council-Arthritis Research UK Centre for Musculoskeletal Ageing Research, Clinical, Metabolic and Molecular Physiology, University of Nottingham, Royal Derby Hospital Centre, Derby, United Kingdom.
  • Atherton PJ; Medical Research Council-Arthritis Research UK Centre for Musculoskeletal Ageing Research, Clinical, Metabolic and Molecular Physiology, University of Nottingham, Royal Derby Hospital Centre, Derby, United Kingdom; philip.atherton@nottingham.ac.uk.
Am J Physiol Endocrinol Metab ; 313(6): E681-E689, 2017 12 01.
Article in En | MEDLINE | ID: mdl-28811296
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Ribosomes / RNA / Biomarkers / Deuterium Oxide / Quadriceps Muscle Limits: Adult / Animals / Female / Humans / Male Language: En Journal: Am J Physiol Endocrinol Metab Year: 2017 Document type: Article
Fulltext
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Ribosomes / RNA / Biomarkers / Deuterium Oxide / Quadriceps Muscle Limits: Adult / Animals / Female / Humans / Male Language: En Journal: Am J Physiol Endocrinol Metab Year: 2017 Document type: Article