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Synthesis of [18 F]Fluoroarenes by Nucleophilic Radiofluorination of N-Arylsydnones.
Narayanam, Maruthi Kumar; Ma, Gaoyuan; Champagne, Pier Alexandre; Houk, Kendall N; Murphy, Jennifer M.
Affiliation
  • Narayanam MK; Department of Molecular and Medical Pharmacology and Crump Institute for Molecular Imaging, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
  • Ma G; Department of Molecular and Medical Pharmacology and Crump Institute for Molecular Imaging, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
  • Champagne PA; Department of Chemistry and Biochemistry, and Department of Chemical and Biomolecular Engineering, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
  • Houk KN; Department of Chemistry and Biochemistry, and Department of Chemical and Biomolecular Engineering, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
  • Murphy JM; Department of Molecular and Medical Pharmacology and Crump Institute for Molecular Imaging, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Angew Chem Int Ed Engl ; 56(42): 13006-13010, 2017 10 09.
Article in En | MEDLINE | ID: mdl-28834065
ABSTRACT
A practical method for radiofluorination of anilines with [18 F]fluoride via N-arylsydnone intermediates is described. These precursors are stable, easy to handle and facilitate direct and regioselective 18 F-labeling to prepare [18 F]fluoroarenes. The value of this methodology is further highlighted by successful application to prepare an 18 F-labeled neuropeptide.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sydnones / Radiopharmaceuticals Language: En Journal: Angew Chem Int Ed Engl Year: 2017 Document type: Article
Fulltext
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sydnones / Radiopharmaceuticals Language: En Journal: Angew Chem Int Ed Engl Year: 2017 Document type: Article