A rat model for studying electroacupuncture analgesia on acute visceral hyperalgesia.
Exp Anim
; 67(1): 51-61, 2018 Feb 09.
Article
in En
| MEDLINE
| ID: mdl-28855444
ABSTRACT
The aim of this study was to establish an appropriate rat model to study the effect of electroacupuncture (EA) analgesia on acute visceral hyperalgesia. Adult rats received colorectal instillation with different concentrations of acetic acid (AA). Treatment with EA was performed for 30 min at bilateral acupoints of ST-36 and ST-37 in the hind limbs. The visceral sensation of all rats was quantified by scores of abdominal withdrawal reflex (AWR) and discharges of rectus abdominis electromyogram (EMG) in response to colorectal distension (CRD). Two hours after instillation of saline (no AA), 1%, 2%, and 4% AA, there were no, slight, moderate and severe visceral hyperalgesia, respectively. Application of EA significantly relieved the visceral hyperalgesia induced by 2% but not 4% AA. The results suggest that 2% AA acute visceral hyperalgesia in adult rats responds well to EA treatment. This may offer an appropriate model for the investigation of EA effects.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Viscera
/
Electroacupuncture
/
Transcutaneous Electric Nerve Stimulation
/
Acetic Acid
/
Disease Models, Animal
/
Hyperalgesia
Type of study:
Prognostic_studies
Limits:
Animals
Language:
En
Journal:
Exp Anim
Year:
2018
Document type:
Article