Your browser doesn't support javascript.
loading
A Ketogenic Diet Extends Longevity and Healthspan in Adult Mice.
Roberts, Megan N; Wallace, Marita A; Tomilov, Alexey A; Zhou, Zeyu; Marcotte, George R; Tran, Dianna; Perez, Gabriella; Gutierrez-Casado, Elena; Koike, Shinichiro; Knotts, Trina A; Imai, Denise M; Griffey, Stephen M; Kim, Kyoungmi; Hagopian, Kevork; McMackin, Marissa Z; Haj, Fawaz G; Baar, Keith; Cortopassi, Gino A; Ramsey, Jon J; Lopez-Dominguez, Jose Alberto.
Affiliation
  • Roberts MN; Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, Davis, CA, USA.
  • Wallace MA; Department of Neurobiology, Physiology, and Behavior, University of California, Davis, Davis, CA, USA.
  • Tomilov AA; Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, Davis, CA, USA.
  • Zhou Z; Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, Davis, CA, USA.
  • Marcotte GR; Department of Neurobiology, Physiology, and Behavior, University of California, Davis, Davis, CA, USA.
  • Tran D; Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, Davis, CA, USA.
  • Perez G; Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, Davis, CA, USA.
  • Gutierrez-Casado E; Departamento de Biología Celular, Fisiología e Inmunología, Universidad de Córdoba, Córdoba, Spain.
  • Koike S; Department of Nutrition, University of California, Davis, Davis, CA, USA.
  • Knotts TA; Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, Davis, CA, USA.
  • Imai DM; Comparative Pathology Laboratory, School of Veterinary Medicine, University of California, Davis, Davis, CA, USA.
  • Griffey SM; Comparative Pathology Laboratory, School of Veterinary Medicine, University of California, Davis, Davis, CA, USA.
  • Kim K; Department of Public Health Sciences, School of Medicine, University of California, Davis, Davis, CA, USA.
  • Hagopian K; Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, Davis, CA, USA.
  • McMackin MZ; Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, Davis, CA, USA.
  • Haj FG; Department of Nutrition, University of California, Davis, Davis, CA, USA.
  • Baar K; Department of Neurobiology, Physiology, and Behavior, University of California, Davis, Davis, CA, USA; Department of Physiology and Membrane Biology, School of Medicine, University of California, Davis, Davis, CA, USA.
  • Cortopassi GA; Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, Davis, CA, USA.
  • Ramsey JJ; Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, Davis, CA, USA. Electronic address: jjramsey@ucdavis.edu.
  • Lopez-Dominguez JA; Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, Davis, CA, USA. Electronic address: jlopez-dominguez@buckinstitute.org.
Cell Metab ; 26(3): 539-546.e5, 2017 Sep 05.
Article in En | MEDLINE | ID: mdl-28877457
ABSTRACT
Calorie restriction, without malnutrition, has been shown to increase lifespan and is associated with a shift away from glycolysis toward beta-oxidation. The objective of this study was to mimic this metabolic shift using low-carbohydrate diets and to determine the influence of these diets on longevity and healthspan in mice. C57BL/6 mice were assigned to a ketogenic, low-carbohydrate, or control diet at 12 months of age and were either allowed to live their natural lifespan or tested for physiological function after 1 or 14 months of dietary intervention. The ketogenic diet (KD) significantly increased median lifespan and survival compared to controls. In aged mice, only those consuming a KD displayed preservation of physiological function. The KD increased protein acetylation levels and regulated mTORC1 signaling in a tissue-dependent manner. This study demonstrates that a KD extends longevity and healthspan in mice.
Subject(s)
Key words
Fulltext
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Health / Diet, Ketogenic / Longevity Limits: Animals Language: En Journal: Cell Metab Year: 2017 Document type: Article
Fulltext
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Health / Diet, Ketogenic / Longevity Limits: Animals Language: En Journal: Cell Metab Year: 2017 Document type: Article