Reduced Slc1a1 expression is associated with neuroinflammation and impaired sensorimotor gating and cognitive performance in mice: Implications for schizophrenia.

Afshari, Parisa; Yao, Wei-Dong; Middleton, Frank A

Afshari, Parisa; Yao, Wei-Dong; Middleton, Frank A.

Affiliation

Afshari P; Department of Neuroscience & Physiology, SUNY Upstate Medical University, Syracuse, NY United States of America.
Yao WD; Department of Neuroscience & Physiology, SUNY Upstate Medical University, Syracuse, NY United States of America.
Middleton FA; Department of Psychiatry & Behavioral Sciences, SUNY Upstate Medical University, Syracuse, NY, United States of America.

PLoS One ; 12(9): e0183854, 2017.

Article in En | MEDLINE | ID: mdl-28886095

Subject(s)

Cognition; Excitatory Amino Acid Transporter 3/genetics; Gene Expression Regulation; Inflammation/genetics; Schizophrenia/genetics; Schizophrenic Psychology; Sensory Gating/genetics; Animals; Anxiety/genetics; Apoptosis; Behavior, Animal; Brain/metabolism; Brain/pathology; Cytokines/metabolism; DNA Damage; Disease Models, Animal; Female; Gene Regulatory Networks; Genotype; Glutathione/metabolism; Haploinsufficiency/genetics; Hippocampus/metabolism; Hippocampus/pathology; Inflammation/immunology; Inflammation/metabolism; Locomotion/genetics; Male; Mice; Mice, Knockout; Oxidation-Reduction; Oxidative Stress; Prefrontal Cortex/metabolism; Prefrontal Cortex/pathology; Schizophrenia/immunology; Schizophrenia/metabolism; Synapses/metabolism

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Full text: 1 Collection: 01-internacional Health context: 6_ODS3_enfermedades_notrasmisibles Database: MEDLINE Main subject: Schizophrenia / Schizophrenic Psychology / Gene Expression Regulation / Cognition / Excitatory Amino Acid Transporter 3 / Sensory Gating / Inflammation Type of study: Prognostic_studies / Risk_factors_studies Limits: Animals Language: En Journal: PLoS One Year: 2017 Document type: Article

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