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Imaging Tunneling Membrane Tubes Elucidates Cell Communication in Tumors.
Lou, Emil; Gholami, Sepideh; Romin, Yevgeniy; Thayanithy, Venugopal; Fujisawa, Sho; Desir, Snider; Steer, Clifford J; Subramanian, Subbaya; Fong, Yuman; Manova-Todorova, Katia; Moore, Malcolm A S.
Affiliation
  • Lou E; Department of Medicine, Division of Hematology, Oncology, and Transplantation, University of Minnesota, Minneapolis, MN 55455, USA; Integrative Biology and Physiology Program, University of Minnesota, Minneapolis, MN 55455, USA. Electronic address: emil-lou@umn.edu.
  • Gholami S; Surgical Oncology Service, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.
  • Romin Y; Molecular Cytology Core Facility, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.
  • Thayanithy V; Department of Medicine, Division of Hematology, Oncology, and Transplantation, University of Minnesota, Minneapolis, MN 55455, USA.
  • Fujisawa S; Molecular Cytology Core Facility, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.
  • Desir S; Department of Medicine, Division of Hematology, Oncology, and Transplantation, University of Minnesota, Minneapolis, MN 55455, USA; Integrative Biology and Physiology Program, University of Minnesota, Minneapolis, MN 55455, USA.
  • Steer CJ; Department of Medicine, Division of Gastroenterology, Hepatology, and Nutrition, University of Minnesota, Minneapolis, MN 55455, USA.
  • Subramanian S; Department of Surgery, University of Minnesota, Minneapolis, MN 55455, USA.
  • Fong Y; Department of Surgery, City of Hope Medical Center, Duarte, CA 91010, USA.
  • Manova-Todorova K; Molecular Cytology Core Facility, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.
  • Moore MAS; Department of Cell Biology, Sloan-Kettering Institute, New York, NY 10021, USA.
Trends Cancer ; 3(10): 678-685, 2017 10.
Article in En | MEDLINE | ID: mdl-28958386
ABSTRACT
Intercellular communication is a vital yet underdeveloped aspect of cancer pathobiology. This Opinion article reviews the importance and challenges of microscopic imaging of tunneling nanotubes (TNTs) in the complex tumor microenvironment. The use of advanced microscopy to characterize TNTs in vitro and ex vivo, and related extensions called tumor microtubes (TMs) reported in gliomas in vivo, has propelled this field forward. This topic is important because the identification of TNTs and TMs fills the gap in our knowledge of how cancer cells communicate at long range in vivo, inducing intratumor heterogeneity and resistance to treatment. Here we discuss the concept that TNTs/TMs fill an important niche in the ever-changing microenvironment and the role of advanced microscopic imaging to elucidate that niche.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cell Communication / Molecular Imaging / Tumor Microenvironment / Neoplasms Limits: Animals / Humans Language: En Journal: Trends Cancer Year: 2017 Document type: Article
Fulltext
Print
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cell Communication / Molecular Imaging / Tumor Microenvironment / Neoplasms Limits: Animals / Humans Language: En Journal: Trends Cancer Year: 2017 Document type: Article