Diosgenin, an Activator of 1,25D3-MARRS Receptor/ERp57, Attenuates the Effects of TNF-&#945; by Causing ADAM10-Dependent Ectodomain Shedding of TNF Receptor 1.

Yang, Won Seok; Moon, Soo Young; Lee, Mee Jeong; Lee, Eun Kyoung; Park, Su-Kil

Diosgenin, an Activator of 1,25D3-MARRS Receptor/ERp57, Attenuates the Effects of TNF-α by Causing ADAM10-Dependent Ectodomain Shedding of TNF Receptor 1.

Yang, Won Seok; Moon, Soo Young; Lee, Mee Jeong; Lee, Eun Kyoung; Park, Su-Kil.

Affiliation

Yang WS; Division of Nephrology, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
Moon SY; Asan Institute for Life Sciences, Seoul, Republic of Korea.
Lee MJ; Department of Pediatrics, Dankook University College of Medicine, Cheonan, Republic of Korea.
Lee EK; Division of Nephrology, Department of Internal Medicine, Dankook University College of Medicine, Cheonan, Republic of Korea.
Park SK; Division of Nephrology, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.

Cell Physiol Biochem ; 43(6): 2434-2445, 2017.

Article in En | MEDLINE | ID: mdl-29073626

Subject(s)

ADAM10 Protein/metabolism; Biological Transport/drug effects; Diosgenin/pharmacology; Protein Disulfide-Isomerases/metabolism; Receptors, Tumor Necrosis Factor, Type I/metabolism; Tumor Necrosis Factor-alpha/pharmacology; ADAM10 Protein/antagonists & inhibitors; ADAM10 Protein/genetics; Calcium/chemistry; Calcium/metabolism; Calcium Channels, L-Type/chemistry; Calcium Channels, L-Type/metabolism; Cell Membrane/metabolism; Cells, Cultured; Egtazic Acid/analogs & derivatives; Egtazic Acid/chemistry; Egtazic Acid/pharmacology; Endothelial Cells/cytology; Endothelial Cells/drug effects; Endothelial Cells/metabolism; Humans; Intercellular Adhesion Molecule-1/metabolism; Microscopy, Confocal; Protein Disulfide-Isomerases/antagonists & inhibitors; Protein Disulfide-Isomerases/genetics; RNA Interference; RNA, Small Interfering/metabolism; Verapamil/pharmacology

Key words

1,25D3-MARRS receptor/ERp57; A disintegrin and metalloprotease 10; Diosgenin; L-type calcium channel; Tumor necrosis factor receptor 1

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Full text: 1 Collection: 01-internacional Health context: 1_ASSA2030 Database: MEDLINE Main subject: Biological Transport / Tumor Necrosis Factor-alpha / Protein Disulfide-Isomerases / Receptors, Tumor Necrosis Factor, Type I / Diosgenin / ADAM10 Protein Limits: Humans Language: En Journal: Cell Physiol Biochem Year: 2017 Document type: Article

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