Renal function after intravitreal administration of vascular endothelial growth factor inhibitors in patients with diabetes and chronic kidney disease.
J Diabetes Investig
; 9(4): 937-939, 2018 Jul.
Article
in En
| MEDLINE
| ID: mdl-29108104
The present study aimed to determine whether intravitreal administration of vascular endothelial growth factor inhibitors is associated with deterioration of renal function, as seen with systemic administration, in patients with diabetes and chronic kidney disease. Estimated glomerular filtration rates before and after 160 intravitreal injections of vascular endothelial growth factor inhibitors (aflibercept, bevacizumab or ranibizumab) were compared in 69 patients with diabetes and with a baseline estimated glomerular filtration rate <60 mL/min/1.73 m2 . We also determined the incidence of acute kidney injury. The data showed no significant difference in the estimated glomerular filtration rate before and after vascular endothelial growth factor inhibitor administration in all patients and in patient subgroups based on each inhibitor. Furthermore, no episodes of acute kidney injury occurred. In conclusion, intravitreal administration of vascular endothelial growth factor inhibitors is unlikely to be associated with a deterioration of renal function in patients with diabetes and chronic kidney disease.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Recombinant Fusion Proteins
/
Receptors, Vascular Endothelial Growth Factor
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Diabetes Complications
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Renal Insufficiency, Chronic
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Bevacizumab
/
Ranibizumab
Type of study:
Etiology_studies
/
Incidence_studies
/
Observational_studies
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Risk_factors_studies
Limits:
Adult
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Aged
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Aged80
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Female
/
Humans
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Male
/
Middle aged
Language:
En
Journal:
J Diabetes Investig
Year:
2018
Document type:
Article