One-Pot Synthesis of α-Carbonyl Bicyclic Furans via a Sequential Diels-Alder/5-Exo-Dig Cyclization/Oxidation Reaction.
J Org Chem
; 82(23): 12920-12927, 2017 12 01.
Article
in En
| MEDLINE
| ID: mdl-29111730
A new one-pot approach to construct α-carbonyl bicyclic furans from easily accessible diynones is described. This reaction sequence proceeds via a Diels-Alder cycloaddition reaction catalyzed by dimethylaluminum chloride followed by a 5-exo-dig cyclization/oxidation reaction catalyzed by copper(II) chloride. This methodology generates α-carbonyl-functionalized dihydroisobenzofuran derivatives in good to excellent yields.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
J Org Chem
Year:
2017
Document type:
Article