Transcriptomic changes following valproic acid treatment promote neurogenesis and minimize secondary brain injury.

Nikolian, Vahagn C; Dennahy, Isabel S; Higgins, Gerald A; Williams, Aaron M; Weykamp, Michael; Georgoff, Patrick E; Eidy, Hassan; Ghandour, Mohamed H; Chang, Panpan; Alam, Hasan B

Nikolian, Vahagn C; Dennahy, Isabel S; Higgins, Gerald A; Williams, Aaron M; Weykamp, Michael; Georgoff, Patrick E; Eidy, Hassan; Ghandour, Mohamed H; Chang, Panpan; Alam, Hasan B.

Affiliation

Nikolian VC; From the Department of Surgery (V.C.N., I.S.D., A.M.W., M.W., P.E.G., H.E., M.H.G., P.C., H.B.A.), and Department of Computational Medicine & Bioinformatics (G.A.H.), University of Michigan, Ann Arbor, Michigan.

J Trauma Acute Care Surg ; 84(3): 459-465, 2018 03.

Article in En | MEDLINE | ID: mdl-29251707

Subject(s)

Brain Injuries, Traumatic; Brain; Neurons; Transcriptome; Valproic Acid; Animals; Female; Brain/metabolism; Brain/pathology; Brain Injuries, Traumatic/diagnosis; Brain Injuries, Traumatic/drug therapy; Brain Injuries, Traumatic/metabolism; Disease Models, Animal; GABA Agents/therapeutic use; Neurons/drug effects; Neurons/pathology; Polymerase Chain Reaction; Random Allocation; RNA/genetics; Swine; Transcriptome/drug effects; Valproic Acid/therapeutic use

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Brain / Valproic Acid / Transcriptome / Brain Injuries, Traumatic / Neurons Type of study: Diagnostic_studies / Guideline / Prognostic_studies Limits: Animals Language: En Journal: J Trauma Acute Care Surg Year: 2018 Document type: Article

Fulltext

XML

PubMed Links

Search on Google