Discoveries of Extrachromosomal Circles of DNA in Normal and Tumor Cells.
Trends Genet
; 34(4): 270-278, 2018 04.
Article
in En
| MEDLINE
| ID: mdl-29329720
ABSTRACT
While the vast majority of cellular DNA in eukaryotes is contained in long linear strands in chromosomes, we have long recognized some exceptions like mitochondrial DNA, plasmids in yeasts, and double minutes (DMs) in cancer cells where the DNA is present in extrachromosomal circles. In addition, specialized extrachromosomal circles of DNA (eccDNA) have been noted to arise from repetitive genomic sequences like telomeric DNA or rDNA. Recently eccDNA arising from unique (nonrepetitive) DNA have been discovered in normal and malignant cells, raising interesting questions about their biogenesis, function and clinical utility. Here, we review recent results and future directions of inquiry on these new forms of eccDNA.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
DNA, Circular
/
DNA, Mitochondrial
/
DNA, Neoplasm
/
Neoplastic Cells, Circulating
/
Neoplasms
Language:
En
Journal:
Trends Genet
Year:
2018
Document type:
Article