Antiestrogen Therapy Increases Plasticity and Cancer Stemness of Prolactin-Induced ER&#945;<sup>+</sup> Mammary Carcinomas.

Shea, Michael P; O'Leary, Kathleen A; Fakhraldeen, Saja A; Goffin, Vincent; Friedl, Andreas; Wisinski, Kari B; Alexander, Caroline M; Schuler, Linda A

Antiestrogen Therapy Increases Plasticity and Cancer Stemness of Prolactin-Induced ERα⁺ Mammary Carcinomas.

Shea, Michael P; O'Leary, Kathleen A; Fakhraldeen, Saja A; Goffin, Vincent; Friedl, Andreas; Wisinski, Kari B; Alexander, Caroline M; Schuler, Linda A.

Affiliation

Shea MP; Molecular and Environmental Toxicology Program, University of Wisconsin-Madison, Madison, Wisconsin.
O'Leary KA; Department of Comparative Biosciences, University of Wisconsin-Madison, Madison, Wisconsin.
Fakhraldeen SA; Department of Comparative Biosciences, University of Wisconsin-Madison, Madison, Wisconsin.
Goffin V; Department of Oncology, University of Wisconsin-Madison, Madison, Wisconsin.
Friedl A; Inserm Unit 1151, Institut Necker Enfants Malades (INEM), Université Paris Descartes, Paris, France.
Wisinski KB; Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, Wisconsin.
Alexander CM; University of Wisconsin Paul P. Carbone Comprehensive Cancer Center, University of Wisconsin-Madison, Madison, Wisconsin.
Schuler LA; University of Wisconsin Paul P. Carbone Comprehensive Cancer Center, University of Wisconsin-Madison, Madison, Wisconsin.

Cancer Res ; 78(7): 1672-1684, 2018 04 01.

Article in En | MEDLINE | ID: mdl-29363543

Subject(s)

Adenocarcinoma/drug therapy; Breast Neoplasms/drug therapy; Cell Plasticity/drug effects; Estrogen Receptor Antagonists/therapeutic use; Estrogen Receptor alpha/antagonists & inhibitors; Mammary Neoplasms, Animal/drug therapy; Neoplastic Stem Cells/pathology; Adenocarcinoma/chemically induced; Adenocarcinoma/pathology; Animals; Antineoplastic Agents, Hormonal/therapeutic use; Breast Neoplasms/pathology; Cell Proliferation/drug effects; Epithelial-Mesenchymal Transition/drug effects; Estrogen Receptor alpha/metabolism; Female; Fulvestrant/therapeutic use; Humans; Mammary Neoplasms, Animal/chemically induced; Mammary Neoplasms, Animal/pathology; Mice; Prolactin/adverse effects; Tumor Cells, Cultured; Wnt Signaling Pathway/physiology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Neoplastic Stem Cells / Breast Neoplasms / Adenocarcinoma / Mammary Neoplasms, Animal / Estrogen Receptor alpha / Estrogen Receptor Antagonists / Cell Plasticity Type of study: Prognostic_studies Limits: Animals / Female / Humans Language: En Journal: Cancer Res Year: 2018 Document type: Article

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