Mining a Kröhnke Pyridine Library for Anti-Arenavirus Activity.

Miranda, Pedro O; Cubitt, Beatrice; Jacob, Nicholas T; Janda, Kim D; de la Torre, Juan C

Miranda, Pedro O; Cubitt, Beatrice; Jacob, Nicholas T; Janda, Kim D; de la Torre, Juan C.

ACS Infect Dis ; 4(5): 815-824, 2018 05 11.

Article in En | MEDLINE | ID: mdl-29405696

Subject(s)

Antiviral Agents/pharmacology; Arenavirus/drug effects; Data Mining; Drug Discovery; Pyridines/pharmacology; Small Molecule Libraries; Animals; Antiviral Agents/chemical synthesis; Antiviral Agents/chemistry; Arenaviridae Infections/drug therapy; Arenaviridae Infections/virology; Arenavirus/physiology; Cell Line; Chemistry Techniques, Synthetic; Chlorocebus aethiops; Dose-Response Relationship, Drug; Drug Design; Drug Discovery/methods; Drug Evaluation, Preclinical; Lymphocytic choriomeningitis virus/drug effects; Pyridines/chemical synthesis; Pyridines/chemistry; Vero Cells; Virus Replication/drug effects

Key words

Kröhnke pyridine library; anti-LCMV activity; arenavirus; protein−protein interaction

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Antiviral Agents / Pyridines / Arenavirus / Small Molecule Libraries / Drug Discovery / Data Mining Type of study: Prognostic_studies Limits: Animals Language: En Journal: ACS Infect Dis Year: 2018 Document type: Article

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