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MEK drives BRAF activation through allosteric control of KSR proteins.
Lavoie, Hugo; Sahmi, Malha; Maisonneuve, Pierre; Marullo, Sara A; Thevakumaran, Neroshan; Jin, Ting; Kurinov, Igor; Sicheri, Frank; Therrien, Marc.
Affiliation
  • Lavoie H; Institute for Research in Immunology and Cancer Laboratory of Intracellular Signaling Université de Montréal C.P. 6128, Succursale Centre-Ville Montréal, Québec H3C 3J7, Canada.
  • Sahmi M; Institute for Research in Immunology and Cancer Laboratory of Intracellular Signaling Université de Montréal C.P. 6128, Succursale Centre-Ville Montréal, Québec H3C 3J7, Canada.
  • Maisonneuve P; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario M5G 1X5, Canada.
  • Marullo SA; Institute for Research in Immunology and Cancer Laboratory of Intracellular Signaling Université de Montréal C.P. 6128, Succursale Centre-Ville Montréal, Québec H3C 3J7, Canada.
  • Thevakumaran N; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario M5G 1X5, Canada.
  • Jin T; Department of Biochemistry, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
  • Kurinov I; Institute for Research in Immunology and Cancer Laboratory of Intracellular Signaling Université de Montréal C.P. 6128, Succursale Centre-Ville Montréal, Québec H3C 3J7, Canada.
  • Sicheri F; NE-CAT APS, Building 436E, Argonne National Laboratory, 9700 S. Cass Avenue, Argonne, Illinois 60439, USA.
  • Therrien M; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario M5G 1X5, Canada.
Nature ; 554(7693): 549-553, 2018 02 22.
Article in En | MEDLINE | ID: mdl-29433126
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Protein Kinases / Mitogen-Activated Protein Kinase Kinases / Proto-Oncogene Proteins B-raf Type of study: Prognostic_studies Limits: Humans Language: En Journal: Nature Year: 2018 Document type: Article
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Protein Kinases / Mitogen-Activated Protein Kinase Kinases / Proto-Oncogene Proteins B-raf Type of study: Prognostic_studies Limits: Humans Language: En Journal: Nature Year: 2018 Document type: Article