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A Preexisting Rare PIK3CAE545K Subpopulation Confers Clinical Resistance to MEK plus CDK4/6 Inhibition in NRAS Melanoma and Is Dependent on S6K1 Signaling.
Romano, Gabriele; Chen, Pei-Ling; Song, Ping; McQuade, Jennifer L; Liang, Roger J; Liu, Mingguang; Roh, Whijae; Duose, Dzifa Y; Carapeto, Fernando C L; Li, Jun; Teh, Jessica L F; Aplin, Andrew E; Chen, Merry; Zhang, Jianhua; Lazar, Alexander J; Davies, Michael A; Futreal, P Andrew; Amaria, Rodabe N; Zhang, David Y; Wargo, Jennifer A; Kwong, Lawrence N.
Affiliation
  • Romano G; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
  • Chen PL; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas.
  • Song P; Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
  • McQuade JL; Department of Bioengineering, Rice University, Houston, Texas.
  • Liang RJ; Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
  • Liu M; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
  • Roh W; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
  • Duose DY; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas.
  • Carapeto FCL; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
  • Li J; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
  • Teh JLF; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas.
  • Aplin AE; Department of Cancer Biology, Thomas Jefferson University, Philadelphia, Pennsylvania.
  • Chen M; Department of Cancer Biology, Thomas Jefferson University, Philadelphia, Pennsylvania.
  • Zhang J; Department of Cutaneous Biology and Dermatology, Thomas Jefferson University, Philadelphia, Pennsylvania.
  • Lazar AJ; Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania.
  • Davies MA; Department of Neurooncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
  • Futreal PA; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas.
  • Amaria RN; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
  • Zhang DY; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas.
  • Wargo JA; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
  • Kwong LN; Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Cancer Discov ; 8(5): 556-567, 2018 05.
Article in En | MEDLINE | ID: mdl-29496665
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Signal Transduction / Drug Resistance, Neoplasm / Ribosomal Protein S6 Kinases, 70-kDa / Class I Phosphatidylinositol 3-Kinases / GTP Phosphohydrolases / Melanoma / Membrane Proteins / Mutation Type of study: Diagnostic_studies / Prognostic_studies Limits: Animals / Female / Humans / Middle aged Language: En Journal: Cancer Discov Year: 2018 Document type: Article
Fulltext
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Signal Transduction / Drug Resistance, Neoplasm / Ribosomal Protein S6 Kinases, 70-kDa / Class I Phosphatidylinositol 3-Kinases / GTP Phosphohydrolases / Melanoma / Membrane Proteins / Mutation Type of study: Diagnostic_studies / Prognostic_studies Limits: Animals / Female / Humans / Middle aged Language: En Journal: Cancer Discov Year: 2018 Document type: Article