Noninvasive visualization of early osteoarthritic cartilage using targeted nanosomes in a destabilization of the medial meniscus mouse model.

Cho, Hongsik; Kim, Byoung Ju; Park, Sang-Hyug; Hasty, Karen A; Min, Byoung-Hyun

Cho, Hongsik; Kim, Byoung Ju; Park, Sang-Hyug; Hasty, Karen A; Min, Byoung-Hyun.

Affiliation

Cho H; Department of Orthopaedic Surgery and Biomedical Engineering, University of Tennessee Health Science Center-Campbell Clinic.
Kim BJ; Veterans Affairs Medical Center, Memphis, TN, USA.
Park SH; Department of Molecular Science and Technology, Ajou University.
Hasty KA; Cell Therapy Center, Ajou University Hospital, Suwon.
Min BH; Department of Biomedical Engineering, Pukyong National University, Nam-Gu, Busan.

Int J Nanomedicine ; 13: 1215-1224, 2018.

Article in En | MEDLINE | ID: mdl-29535518

Subject(s)

Menisci, Tibial/diagnostic imaging; Nanoparticles/chemistry; Nanoparticles/therapeutic use; Osteoarthritis/diagnostic imaging; Animals; Antibodies, Monoclonal/chemistry; Antibodies, Monoclonal/metabolism; Collagen Type II/immunology; Collagen Type II/metabolism; Disease Models, Animal; Fluorescent Dyes/chemistry; Fluorescent Dyes/therapeutic use; Male; Menisci, Tibial/pathology; Mice, Inbred C57BL; Optical Imaging/methods; Osteoarthritis/metabolism; Osteoarthritis/pathology

Key words

OA score; destabilization of the medial meniscus; diagnosis; matrix metalloproteinases; monoclonal anti-type II collagen antibody; nanosome; osteoarthritis

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Full text: 1 Collection: 01-internacional Health context: 6_ODS3_enfermedades_notrasmisibles Database: MEDLINE Main subject: Osteoarthritis / Menisci, Tibial / Nanoparticles Type of study: Prognostic_studies / Screening_studies Limits: Animals Language: En Journal: Int J Nanomedicine Year: 2018 Document type: Article

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