Integrated population pharmacokinetics of etirinotecan pegol and its four metabolites in cancer patients with solid tumors.

Sy, Sherwin K B; Chia, Yen Lin; Gordi, Toufigh; Hoch, Ute; Eldon, Michael A

Sy, Sherwin K B; Chia, Yen Lin; Gordi, Toufigh; Hoch, Ute; Eldon, Michael A.

Affiliation

Sy SKB; Department of Clinical Pharmacology, Nektar Therapeutics, 455 Mission Bay Blvd South, San Francisco, CA, 94158, USA.
Chia YL; Department of Clinical Pharmacology, Nektar Therapeutics, 455 Mission Bay Blvd South, San Francisco, CA, 94158, USA.
Gordi T; Department of Clinical Pharmacology, Nektar Therapeutics, 455 Mission Bay Blvd South, San Francisco, CA, 94158, USA.
Hoch U; Department of Clinical Pharmacology, Nektar Therapeutics, 455 Mission Bay Blvd South, San Francisco, CA, 94158, USA.
Eldon MA; Department of Clinical Pharmacology, Nektar Therapeutics, 455 Mission Bay Blvd South, San Francisco, CA, 94158, USA. meldon@nektar.com.

Cancer Chemother Pharmacol ; 81(5): 897-909, 2018 05.

Article in En | MEDLINE | ID: mdl-29564497

Subject(s)

Antineoplastic Agents/pharmacokinetics; Heterocyclic Compounds, 4 or More Rings/pharmacokinetics; Models, Biological; Neoplasms/drug therapy; Polyethylene Glycols/pharmacokinetics; Adult; Aged; Aged, 80 and over; Antineoplastic Agents/administration & dosage; Antineoplastic Agents/metabolism; Camptothecin/analogs & derivatives; Camptothecin/metabolism; Camptothecin/pharmacokinetics; Clinical Trials as Topic; Female; Glucuronosyltransferase/genetics; Glucuronosyltransferase/metabolism; Heterocyclic Compounds, 4 or More Rings/administration & dosage; Heterocyclic Compounds, 4 or More Rings/metabolism; Humans; Irinotecan/metabolism; Irinotecan/pharmacokinetics; Male; Middle Aged; Polyethylene Glycols/administration & dosage; Polyethylene Glycols/metabolism

Key words

Breast cancer; Etirinotecan pegol; Irinotecan; Population pharmacokinetics; SN38

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Polyethylene Glycols / Heterocyclic Compounds, 4 or More Rings / Models, Biological / Neoplasms / Antineoplastic Agents Limits: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Language: En Journal: Cancer Chemother Pharmacol Year: 2018 Document type: Article

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