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Placentation-related processes in a human first-trimester extravillous trophoblast cell line (HTR-8/SVneo cells) are affected by several xenobiotics.
Correia-Branco, Ana; Keating, Elisa; Martel, Fátima.
Affiliation
  • Correia-Branco A; a Unit of Biochemistry, Department of Biomedicine, Faculty of Medicine , University of Porto , Porto , Portugal.
  • Keating E; b I3S, Instituto de Investigação e Inovação em Saúde, University of Porto , Porto , Portugal.
  • Martel F; a Unit of Biochemistry, Department of Biomedicine, Faculty of Medicine , University of Porto , Porto , Portugal.
Drug Chem Toxicol ; 42(5): 541-545, 2019 Sep.
Article in En | MEDLINE | ID: mdl-29722551
ABSTRACT
Our aim was to investigate the effect of some xenobiotics on placentation-related processes in an extravillous trophoblastic cell line (HTR-8/SVneo cells). Amphetamine, MDMA, theophylline, and fluoxetine, but not nicotine, cocaine, and caffeine, had a negative effect on cell proliferation rates, culture growth, viability, or migratory capacity. These compounds have a detrimental effect in placentation-related processes of HTR-8/SVneo cells.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Placentation / Trophoblasts / Xenobiotics / Cell Movement / Apoptosis / Cell Proliferation Limits: Female / Humans / Pregnancy Language: En Journal: Drug Chem Toxicol Year: 2019 Document type: Article
Fulltext
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Placentation / Trophoblasts / Xenobiotics / Cell Movement / Apoptosis / Cell Proliferation Limits: Female / Humans / Pregnancy Language: En Journal: Drug Chem Toxicol Year: 2019 Document type: Article