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Synthesis and profiling of benzylmorpholine 1,2,4,5-tetraoxane analogue N205: Towards tetraoxane scaffolds with potential for single dose cure of malaria.
O' Neill, Paul M; Stocks, Paul A; Sabbani, Sunil; Roberts, Natalie L; Amewu, Richard K; Shore, Emma R; Aljayyoussi, Ghaith; Angulo-Barturén, Iñigo; Belén, María; Bazaga, Santiago Ferrer; Martínez, María Santos; Campo, Brice; Sharma, Raman; Charman, Susan A; Ryan, Eileen; Chen, Gong; Shackleford, David M; Davies, Jill; Nixon, Gemma L; Biagini, Giancarlo A; Ward, Stephen A.
Affiliation
  • O' Neill PM; Department of Chemistry, University of Liverpool, Liverpool L69 7ZD, United Kingdom. Electronic address: p.m.oneill01@liv.ac.uk.
  • Stocks PA; Department of Chemistry, University of Liverpool, Liverpool L69 7ZD, United Kingdom.
  • Sabbani S; Department of Chemistry, University of Liverpool, Liverpool L69 7ZD, United Kingdom.
  • Roberts NL; Department of Chemistry, University of Liverpool, Liverpool L69 7ZD, United Kingdom.
  • Amewu RK; Department of Chemistry, University of Liverpool, Liverpool L69 7ZD, United Kingdom.
  • Shore ER; Department of Chemistry, University of Liverpool, Liverpool L69 7ZD, United Kingdom.
  • Aljayyoussi G; Research Centre for Drugs and Diagnostics, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, United Kingdom.
  • Angulo-Barturén I; Tres Cantos Medicines Development Campus, DDW, GlaxoSmithKline, Severo Ochoa 2, 28760 Tres Cantos, Spain.
  • Belén M; Tres Cantos Medicines Development Campus, DDW, GlaxoSmithKline, Severo Ochoa 2, 28760 Tres Cantos, Spain.
  • Jiménez-Díaz; Tres Cantos Medicines Development Campus, DDW, GlaxoSmithKline, Severo Ochoa 2, 28760 Tres Cantos, Spain.
  • Bazaga SF; Tres Cantos Medicines Development Campus, DDW, GlaxoSmithKline, Severo Ochoa 2, 28760 Tres Cantos, Spain.
  • Martínez MS; Tres Cantos Medicines Development Campus, DDW, GlaxoSmithKline, Severo Ochoa 2, 28760 Tres Cantos, Spain.
  • Campo B; Medicines for Malaria Venture, ICC, Route de Pré-Bois 20, P.O. Box 1826, 1215 Geneva, Switzerland.
  • Sharma R; Research Centre for Drugs and Diagnostics, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, United Kingdom.
  • Charman SA; Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, VIC 3052, Australia.
  • Ryan E; Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, VIC 3052, Australia.
  • Chen G; Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, VIC 3052, Australia.
  • Shackleford DM; Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, VIC 3052, Australia.
  • Davies J; Research Centre for Drugs and Diagnostics, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, United Kingdom.
  • Nixon GL; Department of Chemistry, University of Liverpool, Liverpool L69 7ZD, United Kingdom.
  • Biagini GA; Research Centre for Drugs and Diagnostics, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, United Kingdom.
  • Ward SA; Research Centre for Drugs and Diagnostics, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, United Kingdom.
Bioorg Med Chem ; 26(11): 2996-3005, 2018 07 15.
Article in En | MEDLINE | ID: mdl-29779669
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Full text: 1 Collection: 01-internacional Health context: 3_ND Database: MEDLINE Main subject: Plasmodium falciparum / Morpholines / Tetraoxanes / Malaria / Antimalarials Limits: Animals / Humans Language: En Journal: Bioorg Med Chem Year: 2018 Document type: Article
Fulltext
Print
XML
PubMed Links
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Full text: 1 Collection: 01-internacional Health context: 3_ND Database: MEDLINE Main subject: Plasmodium falciparum / Morpholines / Tetraoxanes / Malaria / Antimalarials Limits: Animals / Humans Language: En Journal: Bioorg Med Chem Year: 2018 Document type: Article