Revisiting the low birthweight paradox using sibling data with implications for the classification of low birthweight.
J Public Health (Oxf)
; 40(4): e601-e607, 2018 12 01.
Article
in En
| MEDLINE
| ID: mdl-29788352
ABSTRACT
Background:
We examined the birthweight threshold for increased odds of neonatal death among second births based on their elder sibling's birthweight category.Methods:
This population-based cohort study included 190 575 women who delivered their first two non-anomalous singleton live births in Missouri (1989-2005). We examined the birthweight distribution and neonatal mortality curves of second births whose elder sibling had low versus adequate/high birthweight. We determined the optimal cut-off point for the classification of low birthweight among infants in each group based on the Youden index.Results:
Infants whose elder sibling had low birthweight had a lower mean birthweight and a higher percentage of low birthweight infants versus those whose elder sibling had adequate/high birthweight, but low birthweight infants in the former group had a lower rate of neonatal mortality. Upon standardizing the birthweight distribution to a Z-scale, neonatal mortality rates became comparable between the two groups at every rescaled birthweight for Z-scores ≥-3.7. The optimal cut-off point for low birthweight was 2500 and 3000 g among infants whose elder sibling had low and adequate/high birthweight, respectively.Conclusions:
Using sibling data for the classification of LBW may enable the identification of average-sized infants who may be at increased risk of neonatal mortality.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Infant, Low Birth Weight
/
Siblings
Type of study:
Diagnostic_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Humans
/
Infant
/
Newborn
Country/Region as subject:
America do norte
Language:
En
Journal:
J Public Health (Oxf)
Year:
2018
Document type:
Article