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A Novel PET Probe "[18F]DiFA" Accumulates in Hypoxic Region via Glutathione Conjugation Following Reductive Metabolism.
Shimizu, Yoichi; Zhao, Songji; Yasui, Hironobu; Nishijima, Ken-Ichi; Matsumoto, Hiroki; Shiga, Tohru; Tamaki, Nagara; Ogawa, Mikako; Kuge, Yuji.
Affiliation
  • Shimizu Y; Laboratory of Bioanalysis and Molecular Imaging, Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita 12, Nishi 6, Kita-ku, Sapporo, 060-0812, Japan. yshimizu@pharm.hokudai.ac.jp.
  • Zhao S; Central Institute of Isotope Science, Hokkaido University, Kita 15 Nishi 7, Kita-ku, Sapporo, 060-0815, Japan. yshimizu@pharm.hokudai.ac.jp.
  • Yasui H; Kyoto University Hospital, 54 Shogoinkawahara-cho, Sakyo-ku, Kyoto, 606-8507, Japan. yshimizu@pharm.hokudai.ac.jp.
  • Nishijima KI; Graduate School of Medicine, Hokkaido University, Kita 15 Nishi 7, Kita-ku, Sapporo, 060-8638, Japan.
  • Matsumoto H; Central Institute of Isotope Science, Hokkaido University, Kita 15 Nishi 7, Kita-ku, Sapporo, 060-0815, Japan.
  • Shiga T; Graduate School of Medicine, Hokkaido University, Kita 15 Nishi 7, Kita-ku, Sapporo, 060-8638, Japan.
  • Tamaki N; Central Institute of Isotope Science, Hokkaido University, Kita 15 Nishi 7, Kita-ku, Sapporo, 060-0815, Japan.
  • Ogawa M; Research Centre, Nihon Medi-Physics Co., Ltd., 3-1 Kitatode, Sodegaura, Chiba, 299-0266, Japan.
  • Kuge Y; Graduate School of Medicine, Hokkaido University, Kita 15 Nishi 7, Kita-ku, Sapporo, 060-8638, Japan.
Mol Imaging Biol ; 21(1): 122-129, 2019 02.
Article in En | MEDLINE | ID: mdl-29845425
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Full text: 1 Collection: 01-internacional Health context: 1_ASSA2030 Database: MEDLINE Main subject: Fluorine Radioisotopes / Positron-Emission Tomography / Tumor Hypoxia / Glutathione / Hypoxia / Nitroimidazoles Type of study: Diagnostic_studies / Evaluation_studies Limits: Animals / Humans / Male Language: En Journal: Mol Imaging Biol Year: 2019 Document type: Article
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Full text: 1 Collection: 01-internacional Health context: 1_ASSA2030 Database: MEDLINE Main subject: Fluorine Radioisotopes / Positron-Emission Tomography / Tumor Hypoxia / Glutathione / Hypoxia / Nitroimidazoles Type of study: Diagnostic_studies / Evaluation_studies Limits: Animals / Humans / Male Language: En Journal: Mol Imaging Biol Year: 2019 Document type: Article