Aldehyde dehydrogenase 2 polymorphism affects the outcome of methanol poisoning in exposed humans.

Hubacek, J A; Jirsa, M; Bobak, M; Pelclova, D; Zakharov, S

Hubacek, J A; Jirsa, M; Bobak, M; Pelclova, D; Zakharov, S.

Affiliation

Hubacek JA; Center for Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic.
Jirsa M; Center for Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic.
Bobak M; International Institute for Health and Society, Department of Epidemiology and Public Health, University College London, London, UK.
Pelclova D; Toxicological Information Center, Department of Occupational Medicine, First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czech Republic.
Zakharov S; Toxicological Information Center, Department of Occupational Medicine, First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czech Republic.

Clin Genet ; 94(5): 445-449, 2018 11.

Article in En | MEDLINE | ID: mdl-29968299

Subject(s)

Aldehyde Dehydrogenase, Mitochondrial/genetics; Methanol/adverse effects; Pharmacogenomic Variants; Polymorphism, Genetic; Adult; Aged; Alcoholism/complications; Alcoholism/etiology; Alleles; Female; Genotype; Humans; Liver Cirrhosis/etiology; Liver Cirrhosis/pathology; Male; Methanol/poisoning; Middle Aged; Odds Ratio; Polymorphism, Single Nucleotide; Young Adult

Key words

ADH1B; ALDH2; methanol; polymorphism

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Full text: 1 Collection: 01-internacional Health context: 2_ODS3 / 8_ODS3_consumo_sustancias_psicoactivas Database: MEDLINE Main subject: Polymorphism, Genetic / Methanol / Aldehyde Dehydrogenase, Mitochondrial / Pharmacogenomic Variants Type of study: Etiology_studies Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: En Journal: Clin Genet Year: 2018 Document type: Article

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