[Neurologic disorders and Hepatitis E: Review of literature]. / Trouble neurologique et hépatite E : revue de la littérature.
Rev Med Interne
; 39(11): 842-848, 2018 Nov.
Article
in Fr
| MEDLINE
| ID: mdl-30033188
ABSTRACT
INTRODUCTION:
Hepatitis E is an emerging, worldwide disease. It is often asymptomatic. Nevertheless, in few cases, clinical manifestation such as neurological disorder could be present. The aim of this article is to realize a literature review of the neurological symptoms associated with hepatitis E.METHODS:
We searched the Pubmed database using the term "hepatitis E", "neurological disorder AND hepatitis E".RESULTS:
One hundred and thirty cases have been described between 2000 and 2017. The majority of cases were associated with the genotype 3 and were reported in Europe or in Asia. It preferentially affected immunocompetent (93%) men with a median age of 52 years. The main neurologic disorders were Guillain-Barré syndrome (54 cases), Parsonage-Turner syndrome (35 cases), multiplex mononeuropathy (6 cases), meningitis and meningoencephalitis (9 cases). The diagnosis was done with HEV IgM serology in most cases (98%). Aminotranferases increase and cholestasis were found in 88% and 82% respectively. The outcome varied according to the neurological syndrome. Antiviral or immunomodulatory therapies did not seem to improve symptoms.CONCLUSION:
Hepatitis E seems to be associated with acute, wide neurological disorders. These data should be confirmed with a long term prospective study.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Hepatitis E
/
Nervous System Diseases
Type of study:
Diagnostic_studies
/
Observational_studies
/
Risk_factors_studies
Limits:
Humans
Language:
Fr
Journal:
Rev Med Interne
Year:
2018
Document type:
Article