Diagnostic utility of skin autofluorescence when patch test results are doubtful.
Skin Res Technol
; 25(1): 96-99, 2019 Jan.
Article
in En
| MEDLINE
| ID: mdl-30055047
ABSTRACT
BACKGROUND:
The standard diagnostic test for allergic contact dermatitis is the patch test, which can also be used to identify irritant contact dermatitis. Doubtful reactions (?+) can be often clinically relevant to individuals and can require additional tests.OBJECTIVES:
The purpose of this study was to examine whether autofluorescence (AF) measurements in patients with doubtful reactions are helpful in diagnosing contact dermatitis.METHODS:
Patients with a history of contact dermatitis were patch tested on the upper back for 48-hours of occlusion using aqueous solutions of 5% sodium lauryl sulfate. Reaction intensity was scored, and AF was measured on reactive lesions and non-lesions. Three dermatologists classified the results as positive or negative using the fluorescence photographs of patients with a doubtful reaction.RESULTS:
Among doubtful reactions, the R/G% values were significantly higher in the AF- based positive group than in the negative group (P = .0086). On the other hand, the heterogeneity values of R, G, and B (HR, HG, HB) were significantly lower in the AF-based positive group (P = .0026, .0046, .0004 respectively).CONCLUSIONS:
Measuring AF along with the clinical readings can help confirm doubtful patch test reactions.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Patch Tests
/
Dermatitis, Allergic Contact
/
Optical Imaging
Type of study:
Diagnostic_studies
/
Prognostic_studies
Limits:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Skin Res Technol
Year:
2019
Document type:
Article