Susceptibility of Antibody CDR Residues to Chemical Modifications Can Be Revealed Prior to Antibody Humanization and Aid in the Lead Selection Process.

Xu, Ankai; Kim, Hok Seon; Estee, Samarkand; ViaJar, Sharon; Galush, William J; Gill, Avinash; Hötzel, Isidro; Lazar, Greg A; McDonald, Paul; Andersen, Nisana; Spiess, Christoph

Xu, Ankai; Kim, Hok Seon; Estee, Samarkand; ViaJar, Sharon; Galush, William J; Gill, Avinash; Hötzel, Isidro; Lazar, Greg A; McDonald, Paul; Andersen, Nisana; Spiess, Christoph.

Mol Pharm ; 15(10): 4529-4537, 2018 10 01.

Article in En | MEDLINE | ID: mdl-30118239

Subject(s)

Antibodies/immunology; Amino Acid Sequence; Animals; Chromatography, Liquid; Deamination; Hydrogen-Ion Concentration; Isomerism; Methionine/chemistry; Mice; Oxidation-Reduction; Tandem Mass Spectrometry; Tryptophan/chemistry

Key words

deamidation; developability assessment; isomerization; oxidation

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Antibodies Limits: Animals Language: En Journal: Mol Pharm Year: 2018 Document type: Article

Fulltext

XML

PubMed Links

Search on Google